白细胞介素-8在哮喘发病中的作用

Role of interleukin-8 in pathogenesis of asthma

目的 探讨白细胞介素 - 8(IL- 8)在哮喘发病中的作用。方法 对 30例不同时期哮喘患者和 30例正常对照组血浆 IL- 8浓度进行测定 ,并同时检测一秒用力呼气容积 (FEV1 )。结果 哮喘患者急性发作期血浆 IL- 8水平显著高于哮喘缓解期及正常对照组 ,且与 FEV1 水平呈显著负相关。结论 哮喘患者发作期血浆 IL - 8增多 ,它与哮喘免疫炎性细胞上的受体结合 ,趋化和激活炎性细胞 ,参与和调节炎性细胞在气道内的浸润 ,促进气道炎症和气道高反应的形成 ,IL - 8可作为哮喘急性发作的血清学指标之一。

Objective To investigate the role of IL 8 in asthma.Methods The levels of plasma IL 8 and forced expiratory volume in 1 second(FEV 1) in 30 patients with asthma at different stages and 30 normal controls were measured.Results The levels of plasma IL 8 in asthmatic patients at acute stage was significantly higher than those at recovery stage and in normal controls,correlating negatively with FEV 1.Conclusion Level of plasma IL 8 in asthmatic patients increases at acute state,being involved in inflammatory infiltration and formation of airtract heypersensitivity.IL 8 can be regarded as one of indexes of acute bronchial asthma.