昆明山海棠对CIA HIF-1α的影响

Effect of THH in CIA on HIF-1α expression

目的:探讨昆明山海棠(THH)对胶原诱导性大鼠关节炎(CIA)大鼠模型中对于低氧诱导因子(HIF-1α)表达的影响。方法:建立胶原诱导性关节炎(CIA)模型,动态观察关节炎指数(AI)与HE染色关节的病理改变,免疫组化法检测HIF-1α表达。结果:THH的高中低治疗组以及地塞米松治疗组与CIA模型组和正常对照组中的HIF-1α表达有统计学意义(P<0.05)。结论:THH治疗CIA具有明显疗效,提示其作用机制与调节滑膜组织内的HIF-1α的表达有关。

Objective： To investigate the effect of Tripterygium hypoglaucum Hutch（THH） in collagen-induced arthritis（CIA） in the mouse model on the hypoxia inducible factor 1α（HIF-1α） expression.Methods： CIA model was established to perform dynamic observation on the arthritis index（AI） and the pathological changes of HE dyeing joints,and the HIF-1α expression was detected by immunohistochemical method.Results： HIF-1a expression in the THH treatment group（with high,moderate and low dose） high school low,the dexamethasone treatment group,the CIA model group and the normal control group＇s showed statistical differences（P〈0.05）.Conclusion： Treating CIA model with THH is very effective,which indicates that the function mechanism of THH is correlated with the HIF-1α expression adjusting the synovial membrane tissue is connected.