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猪布氏杆菌S2株BvrR基因的克隆与分析 被引量：1

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摘要 布氏杆菌病是由布氏杆菌（Brucella）引起的人兽共患传染病，引起流产、不育和各种组织的局部病灶，严重地威胁着人和多种动物的身体健康。布氏杆菌感染人畜后，可进入机体细胞内生存发育。研究发现，BvrR／BvrS双组分调节系统（TCSBvrRS）和Ⅳ分泌系统VirB（T4SSVirB）在其细胞内生存和致病能力方面具有重要的作用。
作者 杨东东 何剑斌 陈博 刘宝山 石秀颖
机构地区 沈阳农业大学畜牧兽医学院 中国医科大学基础医学院 抚顺市顺城区前甸镇人民政府
出处 《黑龙江畜牧兽医》 CAS 北大核心 2012年第6期118-119,共2页 Heilongjiang Animal Science And veterinary Medicine
关键词 布氏杆菌病 R基因 人兽共患传染病 克隆 身体健康 致病能力 分泌系统 调节系统
分类号 S852.61 [农业科学—基础兽医学]
  • 相关文献

参考文献6

  • 1MARTINEZ - NUNEZ C, ALTAMIRANO - SILVA P, ALVARADO - GUILLEN F,et al. The two - component system BvrR/BvrS regulates the expression of the typeⅣ secretion system VirB in Brucella abor- tus [ J ]. J Bacteriol,2010,192 ( 21 ) : 5603 - 5608.
  • 2SIEIRA R,AROCENA G M,BUKATA L,et al. Metabolic control of virulence genes in Brucella abortus: HutC coordinates VirB expres- sion and the histidine utilization pathway by direct binding to both promoters [ J ]. J Bacterio1,2010,192 ( 1 ) : 217 - 224.
  • 3丁家波,毛开荣,程君生,戴志红,蒋玉文.布氏杆菌病疫苗的应用和研究现状[J].微生物学报,2006,46(5):856-859. 被引量：56
  • 4GUZMAN - VERRI C, MANTEROLA L, SOLA - LANDA A, et al. The two - component System BvrR/BvrS essential for Brucella abor- tus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaeeae [ J ]. Proc Natl Acad Sci USA.2002.99(19) : 12375 -12380.
  • 5MANTEROLA L,GUZMAN - VERRI C, CHAVES - OLARTE E ,et al. BvrR/BvrS - controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence [ J ]. Infect Immun,2007,75 (10) : 4867 - 4874.
  • 6LOPEZ- GONI I, GUZMAN- VERRI C, MANTEROLA L,et al. Regulation of Brucella virulence by the two - component system BvrR/BvrS[ J]. Vet Microbio1,2002,90(1/2/3/4) : 329 - 339.

二级参考文献26

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共引文献55

同被引文献7

  • 1LOPEZ-GONI I,GUZMAN-VERRI C,MANTEROLA L,et al.Regulation of Brucella virulence by the two-component system BvrR/Bvr S[J].Vet Microbiol,2002,90(1/2/3/4):329-339.
  • 2VIADAS C,RODRIGUEZ M C,SANGARI F J,et al.Transcriptome analysis of the Brucella abortus BvrR/Bvr S two-component regulatory system[J].PLo S One,2010,5(4):e10216.
  • 3LAMONTAGNE J,BUTLER H,CHAVES-OLARTE E,et al.Extensive cell envelope modulation is associated with virulence in Brucella abortus[J].J Proteome Res,2007,6(4):1519-1529.
  • 4MARTINEZ-NUNEZ C,ALTAMIRANO-SILVA P,ALVARADOGUILLEN F,et al.The two-component system BvrR/Bvr S regulates the expression of the type IV secretion system Vir B in Brucella abortus[J].J Bacteriol,2010,192(21):5603-5608.
  • 5MARTIN-MARTIN A I,SANCHO P,De MIGUEL M J,et al.Quorum-sensing and BvrR/Bvr S regulation,the type IV secretion system,cyclic glucans,and Bac A in the virulence of Brucella ovis:similarities to and differences from smooth brucellae[J].Infect Immun,2012,80(5):1783-1793.
  • 6MANTEROLA L,GUZMAN-VERRI C,CHAVES-OLARTE E,et al.BvrR/Bvr S-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence[J].Infect Immun,2007,75(10):4867-4874.
  • 7王玉飞,陈泽良,黄留玉.布鲁氏菌胞内生存机制研究进展[J].微生物学通报,2007,34(6):1218-1221. 被引量：14

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黑龙江畜牧兽医
2012年 第6期

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