两种甘草酸制剂治疗慢性乙型肝炎疗效比较

Comparison of the Efficacy of Two Glycyrrhizin in Treatment of Chronic Hepatitis B

目的:比较异甘草酸镁注射液与复方甘草酸苷注射液治疗慢性乙型肝炎的临床疗效和安全性。方法:62例慢性乙型肝炎患者随机分为两组,观察组32例给予异甘草酸镁注射液150 mg加入5%～10%葡萄糖注射液250 ml中,ivd qd;对照组给予复方甘草酸苷注射液120 mg加入5%～10%葡萄糖注射液250 ml中,ivd qd。疗程均为4周。观察两组症状、体征、肝功能等指标的变化及药品不良反应。结果:治疗后两组患者的症状、体征、肝功能指标均有明显改善,组间比较差异无统计学意义(P>0.05)。观察组与对照组有效率分别为90.63%、83.33%,差异同样无统计学意义(P>0.05)。两组均未见严重不良反应。结论:异甘草酸镁注射液治疗慢性乙型肝炎疗效确切,安全性好,与复方甘草酸苷注射液临床疗效差异不明显。

bjective：To compare the clinical efficacy and security of magnesium isoglycyrrhizinate injection and compound glycyrrhizin injection in the treatment of patients with chronic hepatitis B.Methods：62 cases of chronic hepatitis B were randomly divided into the observation group and the controlled group,the 32 cases with chronic hepatitis B were treated with 150mg magnesium isoglycyrrhizinate injection and the 30 cases were treated with 120mg compound glycyrrhizin injection once daily for 4 weeks.Symptoms,signs,hepatic function tests and adverse drug reactions were observed.Results： In the two groups,their symptoms,signs,liver function indices were obviously improved and the effective rates of the observation group and the controlled group were 90.63%and 83.33%respectively.There was no significant difference between the two groups（P 0.05）.There was no serious adverse reaction in them.Conclusion：Themagnesium isoglycyrrhizinate injection was obviously effective and safe for the treatment of chronic hepatitis B.The result showed that magnesium isoglycyrrhizinate injection and compound glycyrrhizin injection were not significant.