手性助剂樟脑磺酸酯的合成工艺研究

Studies on Synthesis of Camphor Sulfonate as Chiral Auxiliary

以樟脑磺酸为起始原料,通过两步反应,合成了樟脑磺酸酯,并用IR和1 H NMR进行了表征。优化条件为:n(樟脑磺酰氯)∶n(甲醇)∶n(吡啶)=1.0∶2.5∶4.0,在-5℃下反应2h,樟脑磺酸甲酯的收率达到了73.2%,产品质量分数为99.6%。

Camphor sulfonate was synthesized from camphor sulfoacid by two steps reaction and was charactrized by IR and 1H NMR.The optimum reaction conditions were as follows： n（camphor sulfonyl chloride）∶n（methyl alcohol）∶n（pyridine）=1.0∶2.5∶4.0,reaction temperature-5℃ and reaction time 2 h.The yield of methyl camphor sulfonate was 73.2% with 99.6% purity.