鲍曼不动杆菌的临床分布特点及耐药性分析

Clinical Distribution and Drug Resistance Analysis of Acinetobacter baumannii

调查鲍曼不动杆菌的临床分布及其对抗菌药物的耐药情况,为临床合理用药提供依据。将哈尔滨医科大学第一附属医院临床各种来源的鲍曼不动杆菌1582株采用K-B法进行药敏试验,并对结果进行统计分析。2008至2010年共检出鲍曼不动杆菌1582株,临床分布以ICU最多(484株,占54.5%)。对抗菌药物的耐药率逐年增高,ICU抗菌药物的耐药率明显高于非ICU病区。该菌株对临床常用抗菌药物高度耐药和多重耐药,对亚胺培南和美罗培南耐药率高达90.9%和90.3%。鲍曼不动杆菌耐药情况相对严重,临床须重视鲍曼不动杆菌的感染,加强院內感染的控制及耐药性的监测,根据药敏结果选择合适抗生素,延缓耐药性进程。

Clinical distribution of Acinetobacter baumannii and its resistance against antibiotic medicines was investi-gated to provide foundation for rational use of medicines clinically. 1 582 strains ofA. baumannii isolated from differ-ent clinical departments during 2008 to 2010 were tested for their drug sensitivity with K-B method, and the resultswere carried out statistical analysis. They distributed the most in ICU 484 （54.5%）. Their resistance rate against an-tibiotics become higher year by year and the drug resistance rates in ICU ward was noticeably higher than those in non-ICU ward. The strains were highly resisted against clinically common antibiotics and had multiple drug-resistance. Theresistance rate against imipenem and meropenem was as high as 90.9% and 90.3% respectively. Drug-resistance ofA. baumannii in the hospital was relatively serious, therefore, the infection of A. baumannii must be attached impor-tance to, and strengthen the control of nosocomial infection and monitoring drug resistance, select the appropriate anti-biotic based on sensitivity test results to postpone the process of drug resistance.