依达拉奉联合乌司他丁对急性肺损伤患者的影响研究

Effects of Edaravone Associate with Ulinastatin in Patients with Acute Lung Injury

目的探讨依达拉奉联合乌司他丁对急性肺损伤患者的肺保护作用及其对炎性因子和氧自由基的影响。方法急性肺损伤患者60例,随机分为两组。对照组常规治疗,治疗组在常规治疗基础上加用依达拉奉和乌司他丁静脉滴注,观察患者治疗前后呼吸频率(RR)、动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)的变化和静脉血中不同时间点白细胞介素-6(IL-6)、血浆肿瘤坏死因子-α(TNF-α)及超氧化物歧化酶(SOD)的变化。结果治疗3d后,治疗组患者RR、PaO2、PaO2/FiO2均优于对照组(P<0.05),治疗后的第1天、第3天、第5天及第7天,两组间TNF-α、IL-6分别比较,差异有统计学意义(P<0.05)。且随着治疗时间的延长,TNF-α、IL-6的检测值均呈下降趋势。治疗前及治疗后两组间SOD的含量呈下降趋势,但治疗组SOD的活力明显高于对照组(P<0.05)。结论依达拉奉联合乌司他丁治疗急性肺损伤,有利于抑制炎性因子、氧自由基,减轻急性肺损伤过度炎症反应及脂质过氧化引起的损伤。

Objective To investigate the effects of edaravone associate with ulinastatin on lung protection,inflammatory factors and oxyradica in patients with acute lung injury.Methods 60 ALI patients were randomly divided into control group and trial group.The control group received conventional therapy.The trial group received additional edaravone associate with ulinastatin.Respiratory rate（RR）,arterial partial pressure of oxygen（PaO2）and oxygenation index（PaO2/FiO2） were observed before and after treatment.The changes of IL-6,TNF-αand SOD were tested at different time.Results After treating 3 days,the RR,PaO2 and PaO2/FiO2 in trial group were better than in control group（P0.05）.Comparing the TNF-α and IL-6 after treating 1,3,5,7 days,there were significance difference between the trial group and control group（P0.05）.What′s more,with the time of therpy prolonged,TNF-αand IL-6 showed a downtrend.Before and after treating,SOD showed a downtrend in both groups.But the activity of SOD in trial group was higher than in control group（P0.05）.Conclusion Edaravone combined with ulinastatin can inhibit inflammatory factors and oxyradica while treating patients with ALI,and can relieve the injury induced by excess nflammatory reaction lipid peroxidation.