超敏C-反应蛋白和氨基末端B型脑钠肽前体及肾小球滤过率与冠状动脉病变程度的关系研究

Correlations of High Sensitive C-Reactive Protein,N-Terminal Pro-Brain Natriuretic Peptide Levels,and Estimated Glomerular Filtration Rate with the Severity of Cardiovascular Disease

目的探讨冠心病患者超敏C-反应蛋白(hs-CRP)、氨基末端B型脑钠肽前体(NT-proBNP)和估算肾小球滤过率(eGFR)与不同冠状动脉病变程度的关系。方法选择103例经冠状动脉造影检查的患者,根据冠状动脉病变的程度分为对照组(15例)、单支组(38例)、双支组(25例)、三支组(25例)。测定各组血清hs-CRP、NT-proBNP水平,并计算出eGFR。结果随着冠状动脉病变程度加重,对照组、单支组、双支组、三支组血清NT-proBNP、hs-CRP水平越高,eGFR越低,组间比较差异均有统计学意义(P<0.01)。结论 hs-CRP、NT-proBNP和eGFR水平可指导评估冠状动脉病变严重程度。

Objective To investigate the correlation of serum high sensitive C-reactive protein（hs-CRP） and N-terminal pro-brain natriuretic peptide（NT-proBNP） levels and estimated glomerular filtration rate（eGFR）with the severity of angiographic coronary artery disease.Methods A total of 103 patients who had undergone coronary angiography were enrolled in this study.They were divided into four groups based on the severity of cardiovascular disease：control group（n=15）,single-vessel disease group（n=38）,two-vessel disease group（n=25）,and three-vessel disease group（n=25）.The serum concentrations of hs-CRP and NT-proBNP were determined and the eGFR was calculated in the four groups.Results Serum hs-CRP and NT-proBNP levels were significantly higher and eGFR significantly lower in groups with severer diseases（P0.01）.Conclusion The serum hs-CRP and NT-proBNP levels and eGFR can be used for assessing the severity of coronary artery disease.