巴豆炮制新工艺及其生品与炮制品的对比研究

New Processing Procedure for Croton tiglium with Study on Comparison of Croton tiglium and Processed Product

目的:建立一种新的巴豆炮制工艺,提供一种更简便、更高效、更安全的炮制方法,得到稳定的、低毒的巴豆炮制品。方法:以巴豆中的有效成分巴豆苷和有毒成分巴豆毒蛋白的含量作为监控指标,设立不同温度、不同厚度和不同烘制时间进行考察,确立好各因素水平后,以最佳烘制工艺炮制得到一批巴豆,将其与生巴豆作急性毒性试验与胃肠推进试验的对比研究。结果:最佳烘制工艺为烘制温度180℃,铺放厚度3 cm,烘制时间90 min。生品的LD50为888 mg/kg,炮制品的LD50为2139 mg/kg。结论:该炮制工艺经济简便、安全高效,值得推广应用。

Objective： To build a new processing procedure for Croton tiglium,providing a more simple,efficient and safe way of processing.Methods：Used the contents of isoguanosine and toxic protein in Croton tiglium as the indexes to investigate the effect of different temperature,thickness and baked time on processing for Croton tiglium.After established all factors and levels,processed a batch of Croton tiglium under optimum processing conditions and compared it with raw Croton tiglium in the test of acute toxicity and gastrointestinal propulsive motility.Results： The parameters of optimum processing were as follows：the temperature was set at 180 ℃,the thickness of placement was 3 cm and baked time was 90 min.The LD50 value of raw Croton tiglium and the processed Croton tiglium was 888 mg/kg and 2139 mg/kg respectively.Conclusion： The processing procedure is simple,affordable,safe and efficient,deserved to promote for application.