补肾活血颗粒治疗帕金森病的“减毒增效”临床研究

Effects of "Attenuation and Synergia" for Bushenhuoxue Granules on Parkinson′s Patients

目的:研究补肾活血颗粒治疗帕金森病(PD)的"减毒增效"临床疗效。方法:将120例PD患者随机分成治疗组60例和安慰剂对照组60例。其中治疗组服用补肾活血颗粒,对照组服用安慰剂,均为2次/天,两组均以美多巴等西药为基础治疗。以3个月为治疗观察期,采用双盲设计,之后带药随访6个月观察。以患者治疗前后症状的变化及美多巴的用量为评价指标。结果:补肾活血颗粒可显著减少PD患者汗多、便秘、排尿障碍等症状的发生,减少美多巴用量,减轻美多巴的副作用(P<0.05)。研究过程中未发现明显不良反应。结论:补肾活血颗粒治疗PD可以达到"减毒增效"的效果,且随着治疗时间的延长作用逐渐显现。

Objective：To study the effects of ＂Attenuation and Synergia＂for Bushenhuoxue Granules（BSHXG）on Parkinson′s patients.Methods：120 patients were enrolled and divided into two groups randomly,the control group were treated with placebo and treatment group with BSHXG,both groups based on Madopar treatment.Double-blinded clinical trial was adopted in treatment period.Follow-up period for 6 months.Usage of Madopar and score of treatment complications were adopted to measure related motor complications before and after treatment.Results：Usage of Madopar and score of treatment complications in treatment group were decreased（P0.05）.No adverse effects were found in this trial.Conclusion：BSHXG can decrease the side-effects of Madopar and put off the development of PD.The effects of ＂Attenuation and Synergia＂ of BSHXG becomes clear with time.