利福布丁联合莫西沙星方案治疗耐多药结核病的疗效观察

Efficacy of Rifabutin Combined Moxifloxacin in Treatmenting MDR-TB

目的:对采用利福布丁与莫西沙星联合的方法对患有耐多药结核病的患者进行治疗的效果进行分析。方法:随机抽取在2005年10月至2010年10月这五年时间里,在我院就诊的患有耐多药结核病的确诊患者病例84例,将其随机分为A、B两组,平均每组42例。A组患者采用口服莫西沙星的方法进行治疗;B组患者采用口服利福布丁加莫西沙星的方法进行治疗。对两组患者的治疗效果进行比较分析。结果:分析结果表明,B组患者的临床治疗效果与A组比较其有效率明显高出很多,有显著的统计学差异(P<0.05);两组患者在用药后均没有出现比较严重的不良反应和并发症现象,没有显著的统计学差异(P>0.05)。结论:采用利福布丁与莫西沙星联合的方法对患有耐多药结核病的患者进行治疗的效果十分明显,没有严重的并发症和不良反应现象,值得使用和推广。

Objective：The use of rifabutin combined with the method of moxifloxacin with MDR-TB patients treated analysis of the effects.Methods：Randomly selected in October 2005 to October 2010 the five-year period in our hospital suffering from MDRTB cases diagnosed in patients 84 cases were randomly divided into A,B groups,the average each group of 42 cases.A group of patients using oral moxifloxacin treatment methods;B patients using oral moxifloxacin Rifabutin method of treatment.The treatment of two groups of patients were compared.Results：The results show that,B group the clinical treatment of patients with the A group was significantly higher than many of its efficiency,a significant statistical difference（P 0.05）;two groups of patients after treatment did not appear in the more serious adverse reactions and complications of the phenomenon,no significant statistical difference（P 0.05）.Conclusion：Rifabutin combined with the method of moxifloxacin with MDR-TB patients for treatment effect is very obvious,no serious complications and adverse phenomenon,worthy of use and promotion.