依达拉奉联合氯吡格雷在治疗急性进展性缺血性脑卒中的临床观察

Clinical Observation of Edaravone Combined with Clopidogrel in the Treatment of Acute Pro-gressive Cerebral Arterial Thrombosis

目的:观察依达拉奉注射液联合氯吡格雷治疗急性进展性缺血性脑卒中的疗效。方法:将78例病人随机分为治疗组和对照组,两组均予常规治疗,对照组给予氯吡格雷治疗,治疗组采用氯吡格雷联合依达拉奉注射液治疗,两组均连续治疗14天后评定疗效及神经功能缺损评分等。结果:治疗组总有效率为63.2%,对照组为52.5%,两组比较有统计学意义(P<0.05)。两组治疗后第14天时神经功能缺损均较治疗前改善明显(P<0.05),且治疗组优于对照组(P<0.05)。结论:依达拉奉注射液联合氯吡格雷治疗进展性卒中疗效优于单用氯吡格雷。

Objective：To observe the clinical effect of Edaravone combined with Clopidogrel in the treatment of acute progressive cerebral infarction.Methods：Acute progressive cerebral infarction were randomly divided into treatment group and control group and the control group received Clopidogrel,edaravone treatment group,combined with Clopidogrel,compared neurological deficits after treatment score and the clinical outcome.Results：After 14 days treatment group,neurological deficit score was（17.2±4.7）minutes,significantly lower than the control group（19.7±5.6）points,the difference was statistically significant（P0.05）;the treatment group were efficiency of 63.2%,significantly higher than 52.5%（P0.05）.Conclusion：Edaravone combined with Clopidogrel progress a significant effect for the treatment of acute progressive cerebral arterial thrombosis.