摘要
目的:观察右旋美托咪啶(Dex)对硬膜外患者的镇静效应及其对呼吸循环的影响,探讨其能否安全有效地应用于硬膜外麻醉患者。方法:选择60例下肢手术患者,行硬膜外麻醉,麻醉平面测试满意后,用微量泵泵注右旋美托咪啶,负荷量0.4μg/kg,10min内泵完,然后以0.2μg/(kg.h)维持输注,记录给药前(T0)、输注负荷量结束即刻(T1)、输注维持量5min(T2),输注维持量10min(T3)、输注维持量30min(T4)、输注维持量1h(T5),停止输注后10min(T6)、停止输注后30min(T7)时的脑电双频谱指数(BIS)、SBP、DBP、MAP、HR、RR、SpO2,并对患者进行OAA/S镇静评分。结果:T1-T7时点患者的SBP、DBP、MAP、SpO2与T0时相比差异无统计学意义,但在T1～T7时点患者的HR明显降低,与T0时相比差异有统计学意义(P<0.05),同时RR在T1～T6时也明显降低,差异亦有统计学意义(P<0.05);T1～T5时点的BIS值与T0时BIS值相比明显降低差异亦有统计学意义(P<0.05);在T1～T6时OAA/S评分明显降低,与T0时的值相比差异亦有统计学意义(P<0.05);但在T7时,BIS、OAA/S评分与T0时相比差异无统计学意义(P>0.05)。结论:右旋美托咪啶可安全有效地应用于硬膜外麻醉患者的术中镇静。
Objective：To evaluate the efficacy and security of dexmedetomidine in patients undergoing epidural anesthesia.Methods：60 patients whose lower limb would be operated were given Dex 0.4μg/kg in 10min as bolus,then were given Dex 0.2μg/（kg.h） by contiuous pump after satisfied epidural anesthesia.BIS,SBP,DBP,MAP,HR,RR and SpO 2 were recorded at T0（before given Dex）,T1（the finished moment after given 0.4μg/kg）;and T2（5min）,T3（10min）,T4（30min）,T5（1h） during the matainance;T6（10min） and T7（30min） after stop drug.Patients＇ sadative degree scores（OAA/S） were evaluated.Results：Compared with T0,SBP,DBP,MAP,SpO 2 at T1～T7 had no significant significance（P0.05）,while HR reduced apparently（P0.05）.RR,OAA/S at T1～T6,BIS of patients at T1～T5 were lower than those at T0 P0.05）.Conclusions：Dexmedetomidine is safe and effective for patient＇s sedation during epidural anesthesia.
出处
《中国医药导刊》
2012年第2期273-274,共2页
Chinese Journal of Medicinal Guide
关键词
右旋美托咪啶
硬膜外麻醉
镇静
Dexmedetomidine
Epidural anaesthesia
Sedation
