急性冠脉综合征与尿酸以及同型半胱氨酸的关系研究

Study of Relationships between Acute Coronary Syndrome and Uric Acid and Homocysteine

目的 ：探讨急性冠脉综合征患者的病情进展与尿酸以及同型半胱氨酸的关系。方法：将2011年1月~2011年8月期间我科收治的急性冠脉综合征患者54例定义为观察组,再根据临床诊断以及冠状动脉造影结果将他们分为急性心肌梗死（AMI）组25例、不稳定型心绞痛（UAP）组29例,将同期收治的非急性冠脉综合征患者28例定义为对照组,现比较这三组患者的尿酸以及同型半胱氨酸水平。结果：AMI组的尿酸水平显著高于UAP组,两组比较差异有统计学意义（P〈0.05）;UAP组的尿酸水平显著高于对照组,两组比较差异有统计学意义（P〈0.05）。AMI组的同型半胱氨酸水平显著高于UAP组,两组比较差异有统计学意义（P〈0.05）;UAP组的同型半胱氨酸水平显著高于对照组,两组比较差异有统计学意义（P〈0.05）。结论：尿酸以及同型半胱氨酸水平与急性冠脉综合征患者的病情进展呈正相关,两者是急性冠脉综合征的危险预测因子。

Objective： To investigate the relationships between the disease situation of patients with acute coronary syndrome and uric acid and homocysteine.Methods： 54 patients with acute coronary syndrome who were admitted into our department from January 2011 to August 2011 were defined as the observation group.According to the clinical diagnosis and the results of coronary angiography,these patients were divided into acute myocardial infarction group（n=25） and unstable angina group（n=29）.In addition,28 patients with non-acute coronary syndrome who were admitted into our department simultaneously were defined as the control group.We compared the uric acid and homocysteine levels among the three groups in this paper.Results： The uric acid level of the AMI group was significantly higher than that of the UAP group（P0.05）,and the uric acid level of the UAP group was significantly higher than that of the control group（P0.05）.The homocysteine level of the AMI group was significantly higher than that of the UAP group（P0.05）,and the homocysteine level of the UAP group was significantly higher than that of the control group（P0.05）.Conclusion： Uric acid and homocysteine level had positive correlation with the disease situation of patients with acute coronary syndrome,and both of them are risk predictor for patients with acute coronary syndrome.