噻托溴铵改善COPD患者急性期临床症状的效果观察

Tiotropium Bromide to Improve the Clinical Symptoms of COPD Patients with Acute Clinical Effects Observed

目的:观察噻托溴铵对COPD患者急性期发作改善临床症状的价值,提高临床治疗水平。方法:选取我院收治的120例COPD急性期发作患者,随机分为观察组(噻托溴铵辅助治疗组)和对照组(常规治疗组)各60例,比较两组患者临床症状改善效果。结果:(1)两组患者咳嗽咯痰、呼吸困难、喘息、湿口罗音等临床症状体征缓解时间比较,差异显著(P<0.05),具有统计学意义。(2)观察组与对照组治疗前后FEV1、FVC、FEV1/FVC、PaO2、PaCO2水平均有明显改变(P<0.05),但观察组改变较对照组明显(P<0.05),具有统计学意义。结论:噻托溴铵可显著改善COPD急性发作患者临床症状及肺功能状态。

Objective： To observe the tiotropium bromide in patients with acute exacerbation of COPD to improve the value of clinical symptoms,improve clinical standards.Methods：In our hospital 120 patients with COPD admitted with acute exacerbation were randomly divided into two groups（tiotropium bromide adjuvant therapy group） and control group（conventional therapy group） of 60 cases,more clinical symptoms improved results.Results：（1）patients were cough,expectoration,dyspnea,wheezing,wet rales and other clinical symptoms and signs of remission time were significant differences（P0.05）,with statistical significance.（2）the observation group and control group before and after treatment FEV1,FVC,FEV1/FVC,PaO2,PaCO2 levels were significantly changed（P0.05）,but changes in the observation group than in the control group was significantly（P0.05）,with statistical significance.Conclusion：Tiotropium bromide significantly improved clinical symptoms in patients with acute exacerbation of COPD and pulmonary function.