根治幽门螺杆菌对胃黏膜肠上皮化生转归的影响

目的研究根除幽门螺杆菌(Hp)感染对胃黏膜肠上皮化生的影响。方法回顾性分析90例慢性胃炎并肠上皮化生伴Hp感染的患者资料。按照随访Hp根除结果不同分为根除组(54例)与未根除组(36例)。观察两组胃黏膜炎肠上皮化生的变化。结果 4年后成功根除Hp的患者肠上皮化生程度明显减轻,与持续Hp感染组比较,差异有统计学意义(P<0.05)。且随访发现根除组肠上皮化生积分(1.25±0.48)分,低于未根除组的(2.23±0.35)分,Hp根除组肠上皮化生积分明显改善,两组相比较差异有统计学意义(P<0.05)。结论根除Hp可以减轻胃黏膜肠上皮化生程度,防止肠上皮化生的进一步发展。

Objective To study the eradication of Helicobacter pylori （Hp） infection to gastric mucosa intestinal metaplasia. Methods We retrospectively analyzed the data of 90 cases of chronic gastritis associated with Hp infection. Hp eradication in accordance with follow-up results were divided into the eradication group and the non-eradication group. Observe the changes in the two groups of gastric mucosal inflammation of intestinal metaplasia.Resluts Compared with continuous Hp infection group, the intestinal metaplasia in Hp eradication group was significantly reduced after four years, the difference was statistically significant （P〈0.05）.And the intestinal metaplasia points in eradication group was lower than the non-eradication group （1.25 ± 0.48 to 2.23 ± 0.35）, the difference was statistically significant（P〈0.05）. Conclusion Hp eradication can reduce the intestinal metaplasia extent,and prevent the further development of intestinal metaplasia.