急性冠状动脉综合征患者外周血单核细胞过氧化物酶体增殖物激活受体γ的表达及意义

Study on peroxisome proliferator activated receptor γ expression in peripheral blood monocyte in acute coronary syndrome

目的:观察急性冠状动脉综合征患者外周血单核细胞过氧化物酶增殖体激活受体γ的表达及其临床意义。方法:选择急性冠状动脉综合征患者67例,20例排除冠心病的成年人为对照组;测定外周血单核细胞过氧化物酶增殖体激活受体γ的表达。结果:急性冠状动脉综合征患者外周血单核细胞过氧化物酶增殖体激活受体γ的表达较对照组低(P<0.05),其中急性心肌梗死患者较不稳定心绞痛患者表达更低(P<0.05)。结论:急性冠状动脉综合征患者过氧化物酶体增殖激活受体γ的表达较对照组降低,外周血单核细胞过氧化物酶增殖体激活受体γ表达水平可反映冠心病患者病情严重程度。

Objective： To observe the expression of peroxisome proliferator activated receptor γ（PPAR γ） in patients with acute coronary syndrome（ACS）.Methods： The expression of PPAR γ in peripheral blood monocyte were detected and analyzed.The study included 67 patients with ACS and 20 controls without coronary heart disease.Results： All patients with ACS reduced the PPAR γ expression in peripheral blood monocyte when compared to the control group（P0.05）.The expression of PPAR γ in patients with AMI was lower than that in patients with unstable angina pectoris（P0.05）.Conlusion： PPAR γ expressed lower in patients with ACS,the expression of PPAR γ may reflect the severity of the patients＇ condition.