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基质金属蛋白酶-1在人涎腺腺样囊性癌细胞中的表达 被引量：3

Expression of MMP-1 in human salivary gland adenoid cystic carcinoma cells
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摘要 目的:测定基质金属蛋白酶-1(MMP-1)在人涎腺腺样囊性癌不同转移力细胞系中的表达。方法:以人涎腺腺样囊性癌ACC-2细胞系及其高转移株ACC-M作为研究肿瘤转移分子机制的模型,采用免疫组化法和蛋白印迹(Western blot)法检测MMP-1的蛋白表达水平。结果:MMP-1在ACC-M细胞中的表达水平高于ACC-2细胞。结论:MMP-1在人涎腺腺样囊性癌的侵袭转移过程中可能发挥作用。 Objective： To study the expression of matrix metalloproteinase 1（MMP-1） in human salivary gland adenoid cystic carcinoma cell lines with different metastatic potential.Methods： The expression of MMP-1 protein in ACC-2 cell line and its highly metastatic cell clone ACC-M was determined by the methods of immunohistochemistry and western blot.Results： Higher expression of MMP-1 protein was determined in ACC-M cells than in ACC-2 cells.Conclusion： MMP-1 may play a role in the metastasis of human salivary gland adenoid cystic carcinoma.
作者 朱秀丽 郭青玉 温德升 王静 吴军正
机构地区 武警总医院口腔科 第四军医大学口腔医学院口腔生物教研室
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2012年第3期324-327,共4页 Journal of Practical Stomatology
基金 国家自然科学基金资助项目(编号:30371551)
关键词 MMP-1 人涎腺腺样囊性癌细胞系 肿瘤转移 MMP-1 Human salivary gland adenoid cystic carcinoma Metastasis
分类号 R739.8 [医药卫生—肿瘤]
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参考文献19

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  • 2Umeda M, Nishimatsu N, Masago H, et al. Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland [ J ]. Oral Surg Oral Med O- ral Pathol Oral Radiol Endod, 1999, 88 (4): 473- 478.
  • 3朱秀丽,吴军正,温德升,郭青玉,王静.基因表达谱芯片技术筛选涎腺腺样囊性癌转移相关基因[J].实用口腔医学杂志,2006,22(4):512-516. 被引量：6
  • 4关晓峰,邱蔚六,何荣根,林国础,周晓健.肺高转移性涎腺腺样囊性癌细胞株的筛选[J].中华口腔医学杂志,1996,31(2):74-77. 被引量：39
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二级参考文献20

  • 1王蘅文，实验肿瘤学基础，1992年
  • 2张青云，中国科学.B，1991年，9卷，951页
  • 3何荣根，华西口腔医学杂志，1988年，6卷，1页
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实用口腔医学杂志
2012年 第3期

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