他克莫司的临床应用评价

Evaluation on The Clinical Application of Tacrolimus

目的:对他克莫司的药动学参数和不良反应等进行评价,为临床合理用药、个体化给药提供有益的信息和依据。方法:查阅他克莫司相关文献,对资料中的药物发生机制和常用药物进行分组,综合评价其临床应用。结果:他克莫司治疗窗窄、生物利用度低、个体差异大、联用时出现不良反应的几率较高。结论:临床上应高度重视他克莫司的合理使用,进行血液浓度监测应综合考虑联合用药等因素,实施个体化给药,保障用药安全。

OBJECTIVE： To evaluate the pharmacokinetic parameters and adverse reactions of tacrolimus so as to provide beneficial references for clinical rational drug use and individualized treatment of this drug.METHODS： By reviewing the relevant literature of tacrolimus,the commonly used medicines were grouped according to the drug interaction mechanism and then their clinical application was evaluated comprehensively.RESULTS： The use of tacrolimus was characterized by narrow therapeutic window,low bioavailability,great individual differences,and high probability of adverse drug reactions when used in drug combination.CONCLUSION： Great importance should be attached to the clinical rational use of tacrolimus.The factor of drug combination should be taken into consideration during monitoring of its blood concentration.Individualized administration of tacrolimus should be recommended to ensure medication safety.