前列地尔治疗早期糖尿病肾脏疾病的预后生存研究

Prognosis and Survival of Patients with Early Stage Diabetic Kidney Disease Treated with Alprostadil

目的:探讨前列地尔对早期糖尿病肾脏疾病患者预后的影响。方法:选择2010年1月—2011年1月在郑州大学第二附属医院诊断且门诊定期随访的早期糖尿病肾脏疾病患者为研究对象,以随机抽样法分为2组,治疗组采用前列地尔治疗,对照组同期给予其他改善循环药治疗。结果:132例随访资料完整的患者随访结束时,前列地尔治疗组显性白蛋白尿、肾小球滤过率下降发生率均低于对照组。结论:前列地尔治疗干预可延缓糖尿病肾脏疾病进展。

OBJECTIVE：To investigate the effect of Alprostadil treatment on the prognosis of patients with early stage diabetic kidney disease.METHODS： The patients with early stage diabetic kidney disease who had regular follow-up visit in the Zhengzhou University Affiliated Second Hospital from Jan.2010 to Jan.2011 were randomized to either Alprostadil group or control group（the patients in the control group were given drugs for improving blood circulation）.RESULTS： At the end of follow-up visits,of a total of 132 cases whose follow-up data were integrated,dominant proteinuria and glomerular filtration rate reduction were all less frequent in the Alprostadil group than in the control group.CONCLUSION： Alprostadil treatment can delay the progression of diabetes kidney disease.