肠出血性大肠杆菌Ⅲ型分泌系统效应因子与宿主细胞相互作用研究进展

Progress of the interactions between type Ⅲ secretion system effector from enterohemorrhagic Escherichia coli and host cells

肠出血性大肠杆菌(Enterohemorrhagic Escherichia coli,EHEC)通过其Ⅲ型分泌系统将效应因子注入到宿主细胞内,破坏宿主细胞内的多种信号通路从而有利于细菌的感染及定植。近年来对于EHEC Ⅲ型分泌系统效应因子与宿主细胞相互作用研究成为EHEC致病机制研究新的热点,研究表明,除了经典的效应因子外,一些新发现的效应因子在细菌的致病过程中也发挥着重要作用,有些效应因子能够抑制宿主细胞内正常的信号通路,有些效应因子还具有抑制细胞凋亡,干扰炎症信号通路和抑制吞噬的作用。这些发现揭示了EHEC效应因子具有多种功能,它们通过与宿主细胞间的相互作用,在细菌的感染过程中发挥着重要作用。

Effectors of Enterohemorrhagic Escherichia coli（EHEC） are translocated into host cells by type Ⅲ secretion system（T3SS） during infection,which block mutiple host cell signaling pathways and promote colonization and infection of EHEC.The interactions between type Ⅲ secretion system effector from enterohemorrhagic Escherichia coli and host cells attracted great concerns in recent years.Study showed that some new effectors play an important role in bacterial pathogenesis besides classical effector.These effectors are able not only to subvert mutiple host cell signaling pathway,but also to inhibit host cell apoptosis and phagocytosis.These findings revealed that EHEC effectors have a variety of functions in bacteria-host cell interaction to benefit EHEC infection.