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ProEXC、p16和Ki-67在宫颈鳞状上皮内肿瘤形成诊断中的应用 被引量：8

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摘要 p16^INK4A（简称p16）被认为是宫颈高危型人乳头状瘤病毒（HPV）感染的一个较好的替代标记。ProEXC是拓扑异构酶Ⅱα（TOP2A）和微小染色体修复蛋白2（MCM2）的鸡尾酒抗体。
作者 杨其昌 刘宏斌 朱燕 张晓娟 沈屹 季晓华
机构地区 江苏省南通大学第二附属医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2012年第6期405-407,共3页 Chinese Journal of Pathology
关键词 P16INK4A KI-67 肿瘤形成 宫颈 高危型人乳头状瘤病毒 上皮内 拓扑异构酶Ⅱα 应用
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1陈杰,常晓燕.宫颈鳞状上皮内肿瘤及相关病变的诊断与鉴别诊断[J].中华病理学杂志,2007,36(8):563-566. 被引量：5
  • 2梅平,刘艳辉,庄恒国,骆新兰,肖克林.p16^(INK4a)在宫颈细胞学鳞状上皮内瘤变中的意义[J].中华病理学杂志,2007,36(8):521-523. 被引量：7
  • 3Galgano MT, Castle PE, Atkins KA, et al. Using biomarkers as objective standards in the diagnosis of cervical biopsies. Am J Surg Pathol, 2010, 34(8): 1077-1087.
  • 4Bergeron C, Ordi J, Schmidt D, et al. Conjunctive p16INK4A testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia. Am J Clin Pathol, 2010, 133 (3) : 395-406.
  • 5Pinto AP, Schlecht NF, Woo TY, et al. Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics. Mod Pathol, 2005, 21 (9) : 1067-1074.
  • 6David O, Cabay RJ, Pasha S, et al. The role of deeper levels and ancillary studies ( p16 (Inkda) and ProExC ) in reducing the discordance rate of Papanicolaou findings of high-grade squamous intraepithelial lesion and follow-up cervical biopsies. Cancer,2009,117 ( 3 ) : 157-166.
  • 7Shi J, Liu H, Wilkerson M, et al. Evaluation of p16INK4a, miniehromosome maintenance protein 2, DNA topoisomerase Ilalpha, ProEX C, and pl6INK4a/ProEX C in cervical squamous intraepithelial lesions. Hum Pathol, 2007, 38 (9) : 1335-1344.
  • 8Kelly D, Kincaid E, Fansler Z, et al. Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytoehemieal assay (ProEx C). Cancer, 2006, 108(6) : 494-500.
  • 9Benevolo M, Mottolese M, Marandino F, et al. Immunohistochemical expression of p16 (INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol, 2006, 19(3) : 384-391.
  • 10马袁英,叶枫,陈晓端,邱丽倩,吕卫国,谢幸.通过子宫颈脱落细胞中P16INK4α的表达预测子宫颈高级别病变的价值[J].中华医学杂志,2010,90(43):3040-3044. 被引量：8

二级参考文献30

  • 1Koss L.The Papanicolaou test for cervical cancer detection:a triumph and a tragedy.JAMA,1989,261:737-743.
  • 2DeFrancesco MA,Gargiulo F,Schreiber C,et al.Detection and genotyping of human papillomavirus in cervical samples from Italian patients.J Med Virol,2005,75:588-592.
  • 3Ekalaksananan T,Pientong C,Sriamporn S,et al.Usefulness of combiningtesting for p16 protein and human papillomavirus (HPV) in cervical carcinoma screening.Gynecol Oncol,2.
  • 4Tsoumpou I,Arbyn M,Kyrgiou M,et al.P16INK4α immunostaining in cytological and histological specimens from the uterine cervix:a systematic review and meta-analysis.Cancer.
  • 5Wentzensen N,Bergeron C,Cas F,et al.Triage of women with ASCUS and LSIL cytology:use of qualitative assessment of P16INK4α positive cells to identify patients with high-.
  • 6Richart R.Cervical intraepithelialn eoplasfa.J P athol,1978,8:301-328.
  • 7Benevolo M,Vocaturo A,Mottolese M,et al.Clinical role of P16INK4α expression in liquid-based cervical cytology:correlation with HPV testing and histologic diagnosis.Am J.
  • 8Schiffman MH,Bauer HM,Hoover RN,et al.Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia.J Natl Cancer Inst.
  • 9Stoler MH,Schiffman M,Atypical squamous cells of undetermine significance-low-grade squamous intraepithelial lesion triage study (ALTS) group.Interobserver reproducibilit.
  • 10Zur Hausen H.Papillomaviruses and cancer:from basic studies to clinical application.Nat Rev Cancer,2002,2:342-350.

共引文献17

同被引文献63

引证文献8

二级引证文献55

中华病理学杂志
2012年 第6期

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