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cAMP-Epac—Rap1信号通路在肾脏疾病中的研究进展 被引量：4

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摘要 环磷酸腺苷（cAMP）是细胞内广泛存在的第二信号分子，在细胞增殖、分化、凋亡等生理病理过程中具有重要效应。
作者 阳石坤 肖力 刘伏友 孙林
机构地区 中南大学肾脏病研究所湖南省血液净化与肾脏病重点实验室湘雅二医院肾内科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2012年第6期498-501,共4页 Chinese Journal of Nephrology
基金 国家自然科学基金（30971379）
关键词 肾脏疾病 信号通路 环磷酸腺苷 信号分子 细胞增殖 病理过程 细胞内
分类号 R692 [医药卫生—泌尿科学]
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参考文献44

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二级参考文献85

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  • 2陈晓岚,张晓娟,范亚平,施岚,俞燕.辛伐他汀对大鼠系膜细胞增殖、凋亡及细胞内半胱氨酸天冬氨酸蛋白酶3表达的影响[J].中华肾脏病杂志,2006,22(2):109-113. 被引量：9
  • 3韩敏,徐钢,曾锐,刘蔚.β-连环素酪氨酸磷酸化调控E-钙黏蛋白表达参与转化生长因子β1诱导的人肾小管上皮细胞转分化[J].中华肾脏病杂志,2006,22(8):494-498. 被引量：21
  • 4Hills CE,Squires PE.TGF-betal-induced epithelial-tomesenchymal transition and therapeutic intervention in diabetic nephropathy.Am J Nephrol,2010,31:68-74.
  • 5Hills CE,Al-Rasheed N,Willars GB,et al.C-peptide reverses TGF-beta1 -induced changes in renal proximal tubular cells:implications for treatment of diabetic nephropathy.Am J Physiol Renal Physiol,2009,296:F614-F621.
  • 6Morsy MD,Hassan WN,Zalat SI.Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats.Diabetol Metab Syndr,2010,2:29-36.
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  • 8Koya D,Hayashi K,Kitada M,et al.Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats.J Am Soc Nephrol,2003,14:S250-S253.
  • 9Du J,Wang L,Liu X,et al.Janus kinase 2/signal transducers and activators of transcription signal inhibition regulates protective effects of probucol on mesangial cells treated with high glucose.Biol Pharm Bull,2010,33:768-772.
  • 10Wang H,Li J,Yu L,et al.Antifibrotic effect of the Chinese herbs,astragalus mongholicus and angelica sinensis,in a rat model of chronic puromycin aminonucleoside nephrosis.Life Sci,2004,74:1645-1658.

共引文献28

同被引文献91

  • 1Haider R.Cheema,Ahmed Al Habash,Essam Al-Askar.Improvement of visual acuity based on optical coherence tomography patterns following intravitreal bevacizumab treatment in patients with diabetic macular edema[J].International Journal of Ophthalmology(English edition),2014,7(2):251-255. 被引量：3
  • 2李雪芹,熊功友,林玲,龚帧,刘建云.百令胶囊与依那普利联合应用对实验性大鼠肾功能的影响[J].中国中药杂志,2004,29(11):1118-1119. 被引量：9
  • 3崔美玉.冬虫夏草治疗IgA肾病30例[J].山东中医杂志,1996,15(5):217-217. 被引量：20
  • 4周红霞,梅柏如,赵丽萍.慢性肾脏疾病中的脂质代谢异常与肾损伤的关系[J].江苏医药,2007,33(11):1179-1179. 被引量：3
  • 5Boer I HD, Rue TC, Cleary PA, et al. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria:an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort[ J]. Arch Intern Med, 2011,171 (5) :412-420.
  • 6Pavkov ME, Knowler WC, Bennett PH, et al. Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians[ J]. Kidney Int ,2006,70 (10) : 1840-1846.
  • 7Stanton RC. Clinical challenges in diagnosis and management of diabetic kidney disease[J]. Am J Kidney Dis,2014,63(2 Suppl 2) :s3-21.
  • 8Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications ( DCCT/EDIC ) Research Group, Nathan DM, Zinman B, et al. Modern-day clinical course of type 1 diabetes mellitus after 30 years ' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience( 1983-2005 ) [ J]. Arch Intern Med ,2009,169 ( 14 ) : 1307-1316.
  • 9Perkins BA FLH, Roshan B,et al. In patients with type 1 diabetes and new-onsetmicroalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria [ J ]. Kidney Int ,2010,77 ( 1 ) :57-64.
  • 10Pezzolesi MG, Jan S, Mychaleckyj JC, et al. Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection[ J]. Semin Nephrol,2010,30(2) : 126-140.

引证文献4

二级引证文献48

中华肾脏病杂志
2012年 第6期

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