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Wnt信号途径在类风湿关节炎骨代谢改变中的作用 被引量：5

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摘要 类风湿关节炎（rheumatoid arthritis，RA）是一种累及周围关节为主的炎性关节病，是国内最常见的风湿病，其发病机制尚未完全明确。在RA疾病过程中骨代谢改变是其主要表现之一，也是研究的热点问题。
作者 王琦 王美美
机构地区 东南大学医学院内科学系 东南大学医学院附属中大医院风湿科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2012年第6期426-429,共4页 Chinese Journal of Rheumatology
关键词 WNT信号途径 类风湿关节炎 骨代谢改变 细胞增殖分化 炎性关节病 发病机制 主要表现 疾病过程
分类号 R593.22 [医药卫生—内科学]
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参考文献2

二级参考文献53

  • 1Gradaigh DO, Ireland D, Bord S, et al. Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor, interleukin 1, and receptor activator of nuclear factor B ligand (RANKL) regulate osteoclasts. Ann Rheum Dis, 2004, 63: 354-359.
  • 2Wagner U, Kaltenhauser S, Pierer M, et al. Prospective analysis of the impact of HLA-DR and -DQ on joint destruction in recent-onset rheumatoid arthritis. Rheumatology, 2003, 42: 553- 562.
  • 3Pettit AR, Walsh NC, Manning C, et al. RANKL protein is expressed at the pannus bone interface at sites of articular bone erosion in rheumatoid arthritis. Rheumatology, 2006, 45: 1068- 1076.
  • 4Mutafchieva M, Williams RO, Funa K, et al. hfflammation is preceded by tumor necrosis factor dependent infiltration of mesenchymal cells in experimental arthritis. Arthritis Rheum, 2002, 46: 507-513.
  • 5Jennifer AK, Ormond AM. Wnt signaling inhibits adipogenesis through-catenin-dependent and -independent me-chanisms.J Biol Chem, 2005, 280: 24004-24010.
  • 6Ivkovic S, Yoon BS, Popoff SN, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development, 2003, 130: 2779-2784.
  • 7Shandala T, Gregory SL, Dalton HE, et al. Citron Kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster.Development, 2004, 131: 5053-5063.
  • 8Dejmek J, Safholm A, Kamp-Melsen C, et al. Wnt-5a/Ca^2+- induced NFAT activity is counteracted by Wnt-5a/Yes-cdc42- casein kinase 1 signaling in human mammary epithelial cells. Mol Cell Biol, 2006, 26: 6024-6036.
  • 9Gonzalez-Sancho JM, Brennan KR, Castelo-Soccio LA, et al. Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-Catenin. Mol Cell Biol, 2004, 24: 4757-4765.
  • 10Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipidmodified and can act as stem cell growth factors. Nature, 2003, 423: 448-452.

共引文献13

同被引文献45

  • 1柯玫瑰,廖军,徐腾.电针大椎穴对大鼠颈椎病模型纤维环细胞FAK蛋白表达的影响[J].福建中医药大学学报,2013,23(4):25-28. 被引量：13
  • 2沈佰华,王利,张继英,聂红,余奇文,陈广洁,程琳玲,柏峻,李宁丽,张冬青,冯国璋,戴号,夏青,胡冬仪,许荣,倪立清.类风湿关节炎患者外周血与病变部位自身反应性T细胞的免疫学特征[J].中华风湿病学杂志,2004,8(8):458-462. 被引量：5
  • 3蒋颖,赵岩,李荣滨,张卓莉,唐福林.重症/难治性结缔组织病患者自体外周血干细胞移植治疗前后TCRBV和CDR3的变化规律[J].基础医学与临床,2007,27(6):629-634. 被引量：1
  • 4Crowson CS,Matteson EL,Davis JM 3rd,et al.Contribution of obesity to the rise in incidence of rheumatoid arthritis[J].Arthritis Care Res (Hoboken),2013,65 (1):71-77.
  • 5Arkema EV,Hart JE,Bertrand KA,et al.Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study[J].Ann Rheum Dis,2013,72(4):506-511.
  • 6Karouzakis E,Gay RE,Michel BA,et al.DNA hypomethylation in rheumatoid arthritis synovial fibrublasts[J].Arthritis Rheum,2009,60(12):3613-3622.
  • 7B(o)hler C,Radner H,Smolen JS,et al.Serological changes in the course of traditional and biological disease modifying therapy of rheumatoid arthritis[J].Ann Rheum Dis,2013,72(2):241-244.
  • 8Dougados M,Devauchelle-Pensec V,Ferlet JF,et al.The ability of synovitis to predict structural damage in rheumatoid arthritis:a comparative study between clinical examination and ultrasound[J].Ann Rheum Dis,2013,72(5):665-671.
  • 9Curtis JR,van der Helm-van Mil AH,Knevel R,et al.Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity[J].Arthritis Care Res (Hoboken),2012,64 (12):1794-1803.
  • 10Sakellariou G,Scirè CA,Verstappen SM,et al.In patients with early rheumatoid arthritis,the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitis[J].Ann Rheum Dis,2013,72(2):245-249.

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二级引证文献117

中华风湿病学杂志
2012年 第6期

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