摘要
In this paper,we introduce our finding of the effects of C_(60) nanoparticles (NP) infiltration on mechanical properties of cell and its membrane.Atomic force microscopy (AFM) is used to perform indentation on both normal and C_(60) infiltrated red blood cells (RBC) to gain data of mechanical characteristics of the membrane.Our results show that the mechanical properties of human RBC membrane seem to be altered due to the presence of C_(60) NPs.The resistance and ultimate strength of the C_(60) infiltrated RBC membrane significantly decrease.We also explain the mechanism of how C_(60) NPs infiltration changes the mechanical properties of the cell membrane by predicting the structural change of the lipid bilayer caused by the C_(60) infiltration at molecular level and analyze the interactions among molecules in the lipid bilayer.The potential hazards and application of the change in mechanical characteristics of the RBCs membrane are also discussed.Nanotoxicity of C_(60) NPs may be significant for some biological cells.
In this paper,we introduce our finding of the effects of C_（60） nanoparticles （NP） infiltration on mechanical properties of cell and its membrane.Atomic force microscopy （AFM） is used to perform indentation on both normal and C_（60） infiltrated red blood cells （RBC） to gain data of mechanical characteristics of the membrane.Our results show that the mechanical properties of human RBC membrane seem to be altered due to the presence of C_（60） NPs.The resistance and ultimate strength of the C_（60） infiltrated RBC membrane significantly decrease.We also explain the mechanism of how C_（60） NPs infiltration changes the mechanical properties of the cell membrane by predicting the structural change of the lipid bilayer caused by the C_（60） infiltration at molecular level and analyze the interactions among molecules in the lipid bilayer.The potential hazards and application of the change in mechanical characteristics of the RBCs membrane are also discussed.Nanotoxicity of C_（60） NPs may be significant for some biological cells.
基金
supported by the National Natural Science Foundation of China (Grant Nos.10902128,11072271,10972239,51172291)
Fundamental Research Funds for the Central Universities,New Century Excellent Talents in University and Research Funds for the Doctoral Program of Higher Education
