CXCR4及VEGF在肾母细胞瘤中的表达及其意义(英文)

Expression and Significance of CXCR4 and VEGF in Nephroblastoma

目的:检测趋化因子受体4(CXCR4)及血管内皮生长因子(VEGF)在肾母细胞瘤中的表达,探讨其在肾母细胞瘤的发生、发展、浸润和转移中的作用。方法:选择临床及病理资料齐全的存档肾母细胞瘤标本30例,另取正常肾脏标本10例作对照。采用免疫组化(SABC)方法检测CXCR4及VEGF的表达。结果:CXCR4在肾母细胞瘤组织中高表达(66.67%),在正常肾脏组织中低表达(30.0%),两者相比有统计学意义(P<0.05),VEGF在肾母细胞瘤组织中高表达(73.33%),在正常肾脏组织中低表达(20.0%),两者相比同样有统计学意义(P<0.05),肾母细胞瘤组织中CXCR4与VEGF的表达两者之间呈正相关性(r=0.392,P<0.05)。结论:肾母细胞瘤组织中CXCR4和VEGF均高表达。CXCR4及VEGF可能成为预测肾母细胞瘤浸润转移的重要指标。

Objective： To detect the expression and significance of CXCR4,VEGF and their correlations in Nephroblastoma,so as to investigate their effect on metastasis and development of the tumor.Methods： SABC immunohistochemistry was used to detect the expression of CXCR4 and VEGF,in 30 samples of Nephroblastoma tissue selected from paraffin wax-embodied specimens with complete clinicopathological data,and other 10 cases of normal kidney tissue.Results： The expression of CXCR4 in normal kidney tissue was lower（30.0%） than that in Nephroblastoma（66.67%）,and the difference was significant（X^2=4.126,P0.05）.The expression of VEGF in Nephroblastoma was higher（73.33%） than that in normal kidney tissue（20.0%） and the difference was also significant（X^2=8.889,P〈0.05）.The expression of CXCR4 was significantly positively correlated with the expression of VEGF in Nephroblastoma（r =0.392,P〈0.05）.Conclusions： CXCR4 and VEGF had highly expression in Nephroblastoma.CXCR4 and VEGF may be served as the markers in the estimation of metastasis and dissemination of Nephroblastoma.