骨性关节炎生物学标志物研究进展

Progress of Stdudy on Biomarkers of Osteoarthritis

骨性关节炎(oseteoarthritis,OA)是一种随着年龄增长发病率明显升高的退行性变,常累及脊柱、髋、膝等人体负重关节,以关节缓慢发展的疼痛、肿胀,伴功能障碍为临床表现,主要有滑膜增生、软骨破坏、软骨下骨骨化及骨赘形成等一系列病理表现。OA对人类的健康和生活质量影响很大,随着老龄化社会的到来,本病的发病率日趋升高,其研究已成为医学领域中的重要课题。目前,OA的早期诊断、病变监测和有效防治仍是骨科领域亟待解决的疑难问题。随着分子生物学的发展和研究手段的提高,许多研究者都在试图寻找用于临床评价OA的生物学标志物。本文将就OA研究中所使用的主要标志物进行综述,为深入研究OA提供方便。

Osteoarthritis is a progressive degeneration whose incidence is increased with age,often involving the vertebral column,hip,and knee joints,characterized by chronic pains,swelling and disfunction clinically and synovial proliferation,cartilage distruction,subchondral bone ossification,osteophyte formed pathologically.OA has great effect on people＇s health and life quality.Along with the arrival of aging society,OA has become an important subject in medical area.Resently,early diagnosis,monitoring and prevention of OA is still a burning question in orthopedic field.With the development of molecular biology and research method,many scholars are trying to find some useful biomarkers for clinic evaluation.This review will provide convenience for further reseach of OA.