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ABCB1与氯吡格雷抵抗的研究进展 被引量：4

Clopidogrel Resistance with ABCB1
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摘要 氯吡格雷和阿司匹林双联抗血小板已是急性冠状动脉综合征和经皮冠脉介入术后的标准治疗,因此氯吡格雷抵抗越来越受到人们的关注,但焦点更多的集中在氯吡格雷氧化代谢基因(P2Y12、CYP3A4等)多态性方面,而对氯吡格雷吸收方面基因多态性的关注相对较少,本文就调控氯吡格雷在肠道吸收的基因(ABCB1)进行综述,并探讨其多态性与氯吡格雷抵抗的关系。 Clopidogrel and aspirin thermodynamic antiplatelet is a postoperative standard treatment of acute coronary syndrome and percutaneous coronary intervention（pci）.People pay more and more attention to clopidogrel resistance,but more focus is concentrated on clopidogrel oxidative metabolism of genes（P2Y12 CYP3A4 etc.）polymorphism,gene polymorphism on absorption is few concerned.The gene（ABCB1） which regulates clopidogrel in intestinal absorption will be reviewed in this article,and discuss the relationship between the polymorphism of ABCB1 and clopidogrel resistance.
作者 路英杰 王立峰 张旭昌 王晓云
机构地区 哈尔滨医科大学附属第四医院心内科
出处 《现代生物医学进展》 CAS 2012年第10期1989-1991,共3页 Progress in Modern Biomedicine
关键词 ABCB1 氯吡格雷 氯吡格雷抵抗 ABCB1 Clopidogrel Clopidogrel resistance
分类号 R54 [医药卫生—心血管疾病] R96 [医药卫生—药理学]
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参考文献17

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同被引文献68

  • 1郝盼盼,陈玉国,张运.氯吡格雷抵抗相关因素的研究进展[J].心血管病学进展,2009,30(6):991-994. 被引量：21
  • 2Breet N], van Werkum ]W, Bouman H], et ai. Comparison of platelet function tests in predicting clinical outcome in patients un- dergoing coronary stent implantation[ J]. JAMA, 2010,303 ( 8 ) : 754-762.
  • 3Takahashi S, Ushida M, Komine R, et al. Platelet responsiveness to in vitro aspirin is independent of COX-I and COX-2 protein lev- els and polymorphisms [J]. Thromb Res, 2008, 121 (4) : 509- 517.
  • 4Gasparyan AY, Watson T, Lip GY. The role of aspirin in cardio- vascular prevention : implications of aspirin resistance [ J ]. J Am Coil Cardiol, 2008,51 (19) : 1829-1843.
  • 5Hedegaard SS, Hvas AM, Grove EL, et al. Optical platelet aggre- gation versus thromboxane metabolites in healthy individuals and patients with stable coronary artery disease after low-dose aspirin administration[ J]. Thromb Res, 2009,124( 1 ) :96-100.
  • 6Pamukcu B, Oflaz H. Impact of genetic polymorphisms on platelet function and aspirin resistance [ J ]. Blood Coagulation Fibrinoly- sis, 2010,21 ( 1 ) :53-56.
  • 7Liu W, Poole EM, Ulrich CM, et al. Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglan- din H synthase-I [ J ]. Pharmacogen Gen ,2012,22 (7) :525-537.
  • 8Cuisset T, Frere C, Quilici J, et al. Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump lnhibitors and Ctnpidogrel Associa- tion) prospective randomized study[J]. J Am Coil Cardiol, 2009, 54(13) : 1 149-1153.
  • 9Sibbing D, Morath T, Stegherr J, et al. Impact of proton pump in- hibitors on the antiplatelet effects of clopidogre [J]. Thromb Hae- most, 2009,101 (4) :714-719.
  • 10Juurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pmnp inhibitors and clopidogrel [J]. CMAJ, 2009,180(7) :713-718.

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现代生物医学进展
2012年 第10期

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