秋茄枝乙醇提取物减轻链脲佐菌素诱导的大鼠肝脏和胰腺病理损伤

Ethanol Extract from Kandelia Candel Trunk Reduces Pathological Damages of Liver and Pancreas in Rats Induced by Streptozotocin

目的:研究秋茄枝乙醇提取物(EEK)对链脲佐菌素(STZ)诱导的2型糖尿病(T2DM)大鼠肝脏和胰腺组织病理结构的影响。方法:以高脂饲料喂养联合STZ建立T2DM大鼠模型。大鼠分为为正常对照组、T2DM模型组、二甲双胍组、EEK低、中、高剂量组。大鼠给药4周后处死,取肝脏和胰腺进行组织病理学检查。结果:随着EEK剂量的增加,大鼠肝脏和胰岛组织的病理损伤逐步减轻。结论:EEK有助于修复STZ诱导的T2DM大鼠受损的肝脏和胰岛组织。

Objective： To investigate the effect of ethanol extract from kandelia candel trunk（EEK） on pathological structure of liver and pancreas in type 2 diabetes mellitus（T2DM） rats induced by streptozotocin.Methods： The T2DM rat model was induced with high-fat diet and STZ.Rats were devided into normal control group,model group,metformin group,EEK low-dose group,EEK medium-dose group and EEK high-dose group.After 4W administration,the rats were sacrificed to perform histopathological examination.Results： The pathological damages of liver and pancreas were gradually reduced with increasing dosages of EEK in Rats Conclusion： EEK contributes to repairing damaged liver and pancreas in T2DM rats induced by STZ.