冠心病患者颈动脉粥样硬化与血管内皮功能的临床研究价值

The Clinical Value of Carotid Artery Atherosclerosis and Endothelial Dysfunction in Coronary Heart Disease Patients

目的:探讨颈动脉粥样硬化与血管内皮功能与冠心病患者的相关性。方法:选取114例冠心病患者(54例单支病变和60例多支病变)为观察组和60例健康体检者为对照组,对两组患者动脉粥样硬化及血管内皮功能进行分析。结果:观察组患者TC、TG、HDL及血糖水平均高于对照组,观察组LDL水平显著低于对照组,两组比较差异有统计学意义(P<0.05);观察组患者颈动脉IMT、斑块积分及斑块数明显高于对照组(P<0.05),观察组FMD显著降低(P<0.05),多支病变组病变程度更严重(P<0.05)。结论:颈动脉粥样硬化与血管内皮功能可作为预测冠心病的重要指标,对预防和治疗冠心病具有重要意义。

Objective： To explore the relationship of carotid artery atherosclerosis and endothelial dysfunction in coronary heart disease patients.Methods： 114 cases of coronary heart disease（54 cases single vessel disease and 60 cases multiple vessel disease）and 60 cases of healthy physical examination were selected.Carotid artery atherosclerosis and endothelial dysfunction were analyzed in two groups.Results： The TC,TG,HDL and blood sugar levels were higher in observation group than in control group,the LDL levels was lower than in control group.The difference between the two groups was significant（P〈0.05）.The IMT,plaque score and plaque numbers were higher than in control group（P〈0.05）,FMD was decreased,the disease severity was serious in multiple vessel disease group.Conclusion： Carotid artery atherosclerosis and vascular endothelium function are the important indicator in predicting coronary heart disease.It has important sense for prevent and treat coronary heart disease.