摘要
Prx1是一种高等生物体内广泛表达的抗氧化酶,在细胞处于不同的氧化状态时,能够以二聚体和十聚体两种不同的形式存在。该蛋白不仅能起到抗氧化和调节H2O2介导的信号转导作用,同时还能发挥分子伴侣的功能,通过细胞信号网络,直接或间接地参与体内多种与氧化相关的生理病理过程,发挥体内氧化还原调节器的重要作用。
Prx1 is an antioxidant enzymes which is widely expressed in higher organisms.In different oxidation states,prx1 exists in two different forms,dimer or decamer.Prx1 is not only involved in the defense system against oxidative stress and in the regulation of H2O2-mediated cellular signaling,but also functions as a chaperone.In these ways,prx1 directly or indirectly involved in the cell signaling netwoks of various physiological and pathological processes related to oxidation,thus plays an important role in redox regulation.
出处
《现代生物医学进展》
CAS
2012年第11期2186-2190,共5页
Progress in Modern Biomedicine
基金
国家重大基础理论研究发展"973"计划项目(2010CB529704)
教育部长江学者和创新团队发展计划项目(IRT0731)
国家自然科学基金重点项目(81030055)
广东省自然基金项目(10251051501000003)
