114株阴沟肠杆菌的耐药性及分布

Drug resistance and distribution in 114 strains of Enterobacter cloacae

目的了解本院阴沟肠杆菌的耐药情况及分布,为临床治疗提供依据。方法用微量稀释法和K-B纸片扩散法检测2010年6月至2011年4月本院临床分离的114株阴沟肠杆菌对亚胺培南等18种抗菌药物的耐药性,并对临床分布情况进行回顾性分析。结果 114株阴沟肠杆菌主要自痰液中检出(73.7%);菌株分散在各病区。对亚胺培南、美罗培南、厄他培南、哌拉西林/他唑巴坦、阿米卡星、左氧氟沙星、环丙沙星、头孢吡肟、妥布霉素、头孢他啶、庆大霉素、头孢噻肟、氨曲南、复方新诺明、阿莫西林/棒酸、头孢西丁、头孢唑啉和氨苄西林的耐药率分别为0.0%、0.0%、0.0%、8.8%、23.7%、29.8%、36.0%、39.5%、44.7%、51.8%、52.6%、58.8%、59.6%、59.6%、86.0%、100.0%、100.0%和100.0%。结论本院所分离的阴沟肠杆菌主要引起呼吸道感染,临床上应根据其耐药特点合理选用抗菌药物。

Objectives To investigate drug resistance and distribution of Enterobacter cloacae in our hospital,in order to guide the clinical therapy. Methods Total of 114 strains of Enterobacter cloacae were collected from Tai’an Central Hospital from June 2010 to April 2011, the drug resistance rates to imipenem and other 17 kinds of antibiotics were tested through Microdilution method and K-B disk diffusion method. Drug resistance and clinical distribution were analyzed, retrospectively. Results Total of 114 strains of Enterobacter cloacae were collected mainly from sputum （73.7%）,and scattered in all the wards. Resistance rates to imipenem, meropenem, ertapenem, piperacillin/tazobactam, amikacin, levofloxacin, ciprofloxacin, cefepime, tobramycin, ceftazidime, cidomycin, cefotaxime, aztreonam, SMZ-TMP, amoxicillin/clavulanic, cefoxitin, cefazolin and ampicillin were 0.0%, 0.0%, 0.0%, 8.8%, 23.7%, 29.8%, 36.0%, 39.5%, 44.7%, 51.8%, 52.6%, 58.8%, 59.6%, 59.6%, 86.0%, 100.0%, 100.0% and 100.0%. Conclusions Enterobacter cloacae isolated in our hospital mostly caused respiratory tract infection. Antibiotics should be chosen according to drug sensitivity test in clinical practice.