RPR和TPPA联合检测在梅毒首诊病人中的应用

The application of combined detection by RPR and TPPA methods in early diagnosis syphilis patients

目的了解RPR和TPPA在梅毒早期诊断中的检测意义。方法收集门诊血清标本3210份，快速血浆反应素环状卡片试验（RP剐和梅毒螺旋体明胶颗粒凝集试验（TPPA）检测。结果收集的3210份标本中，RPR阳性263例，阳性率为8．2％；TPPA阳性为345例，阳性率为10．7％。263例RPR阳性的标本中，有6例为TPPA阴性；345例TPPA阳性的标本中，87例为RPR阴性，进行随访有27例RPR转为阳性。结论RPR与TPPA联合检测在梅毒的早期断中具有非常重要的诊断价值，单一试验的筛查具有局限性。易导致早期梅毒误诊和漏诊。RPR和TPPA联合检测对于减具有十分重要的意义。

Objective To understand the significance of RPR and TPPA test in the diagnosis ot syphilis in the early period. Methods 3210 serum samples were collected outpatient and being tested by rapid plasma reagin （RPR） test and Treponema pallidum particle agglutination assay （TPPA） test. Results in the collected 3210 specimens, 263 specimens were tested as RPR positive, the positive rate is 8.2%; 345 specimens were tested as TPPA positive, the positive rate is 10.7%. Among the 263 positive RPR eases, 6 eases were tested as TPPA negative; Among the 345 positive TPPA eases, 87 eases were tested as RPR negative, in which, during the follow- up, 27 eases of RPR negative change to positive. Conclusion the combination RPR and TPPA test is important in the diagnosis of early syphilis. This method can significantly reduee nfisdiagnosis and missed diagnosis of syphilis in the early period.