摘要
目的观察强化他汀治疗不稳定型心绞痛的效果及可能机制。方法将130例不稳定型心绞痛患者随机分为治疗1组(瑞舒伐他汀钙片10 mg,1次/d,50例)、治疗2组(瑞舒伐他汀钙片20 mg,1次/d,50例)和对照组(常规治疗,30例),测定治疗前及治疗后1周、4周、8周时血清超敏C反应蛋白(hs-CRP)、可溶性CD40配体L(sCD40L)、血脂、肝功能等指标,主要心血管事件(MACE)的发生率以及瑞舒伐他汀的药物不良反应情况。结果与对照组相比较,治疗1组和治疗2组治疗后1周、4周、8周血清hs-CRP、sCD40L、LDL-C水平均降低(P<0.05),治疗1组和治疗2组之间治疗后8周hs-CRP、sCD40L差异有统计学意义(P<0.01)。结论不稳定型心绞痛患者强化他汀治疗,可能通过抗炎、改善内皮、稳定斑块等作用而最终获益。
Objective To investigate the clinical effect and significance of intensive statin on serum hs-CRP and soulable CD40L in unstable angina(UA) patients.Methods 130 UA patients were randomly divided into three groups.The control group(n=30) was given the routine medicine,and the other two therapy groups were administered rosuvastatin with 10 mg(group1) or 20 mg(group2) qd for 8 weeks.Levels of serum hs-CRP,sCD40L and lipid,and the incidences of major adverse cardiovascular events were determined before and after treatment.Results Compared with the control group,the levels of serum hs-CRP,CD40L,LDL-C and the rate of angina attacks were significantly decreased in treatment group 1 and group 2(n=50,P0.05).There was significant difference between group1 ang group2(P0.01).Conclusion Intensive treatment of rosuvastatin is beneficial for UA patients.The possible mechanisms include anti-inflammation,improving the endothelium and stabilizing of plaque.
出处
《中国临床保健杂志》
CAS
2012年第2期147-149,共3页
Chinese Journal of Clinical Healthcare