检测热性惊厥患儿CK-MB和肌钙蛋白Ⅰ的临床意义

Clinical significance of serum CK-MB and cardiac troponinⅠin febrile convulsion children

目的探讨热性惊厥患儿抽搐后肌酸激酶同工酶(CK-MB)及肌钙蛋白Ⅰ(cTnI)的变化及抽搐时间的不同对心肌损害的影响。方法将246例热性惊厥患儿根据抽搐时间分为A组188例和B组58例,分别进行CK-MB及cTnI检测,比较两组患儿的CK-MB及cTnI阳性率。结果两组热性惊厥患儿CK-MB和cTnI均有不同程度的改变,且抽搐时间越长,CK-MB和/或cTnI阳性率越高。两组热性惊厥患儿的CK-MB和cTnI阳性率有统计学差异(P<0.05)。结论热性惊厥可引起患儿心肌损害,抽搐时间越长心肌损害越明显。治疗时要注意保护心肌,以减少并发症的发生。

Objective To explore the clinical detecting significance of the changes of CK-MB and cardiac troponin Ⅰ （cTnI） levels on serum in children with febrile convulsion. Methods From Jan, 246 children who were diagnosed with febrile convulsion were chosen as two experimental group according to the duration of seizure. ELISA detecting method was applied to detect CK-MB and cTnI. Results CK-MB and cTnI level of febrile convulsion had some degree change, there were significant difference associated with time of febrile convulsion. Conclusion It is indicated that febrile convul-sion may be due to heart damage in children, especially, time of febrile convulsion longer.