尘螨特异性免疫治疗对哮喘患儿的干预及对肺功能的影响

Effects of house dust mite specific immunotherapy on immune and pulmonary function of asthmatic children

目的探讨尘螨特异性免疫治疗(SIT)与哮喘患儿IgE的相关性及对肺功能的影响。方法将56例哮喘轻-中度发作期儿童,随机分为A组35例(加用SIT治疗),B组21例(对照组)。在SIT前和SIT后6个月检测过敏原皮试、血浆IgE、肺功能,并进行临床疗效评价。结果 A组SIT后血浆总IgE、尘螨特异性IgE下降,过敏原复查有意义;临床疗效比较,A组有效率93.86%,B组为82%;两组肺通气功能均明显改善。结论 SIT可减少IgE的合成;SIT可明显改善肺通气功能,结合尘螨特异性IgE下降、临床疗效好,为哮喘用药及调整提供客观依据。

Objective To observe the effects on immune and pulmonary function in asthmatic children treated with house dust mite Specific immunotherapy（SIT）. Methods 35 cases（A group ） with SIT whereas 21case（B group） with not of mild and middle asthmatic children were studied. They were observed in skin test, pulmonary function and IgE in plasma using ELISA kits. Results Compared with the control group, the plasma total IgE and Derp was significantly de-creasedt In comparison with the asthma control, SIT could reduce the level of plasma total fgE and Derp specific IgE. Good results could be attained in symptom and pulmonary function. Conclusion We found excellent effects of SIT on im-mune and pulmonary function of asthmatic infants.