血清HE4在诊断妇女盆腔疾病中的应用

Value of human serum levels of human epididymis protein 4 in patients with gynecological pelvic lesions

目的探讨血清HE4对妇女盆腔疾病诊断的临床价值。方法采用ELISA方法测定血清HE4;以术后包块切片病理报告为依据,将其分为5组;以病理诊断为金标准计算血清HE4水平对妇女盆腔恶性疾病的灵敏度和特异度等诊断性能。结果健康对照组血清HE4为(32.52±11.67)pmol/L;各组妇女盆腔疾病中阳性检出率分别为:卵巢癌组100%[(463.05±365.81)pmoL/L]、子宫恶性肿瘤组37.5%[(59.47±40.78)pmoL/L]、卵巢非恶性病变组17.65%[(40.55±18.88)pmoL/L]、子宫非恶性病变组19.23%[(42.74±18.33)pmoL/L];血清HE4水平对妇女盆腔恶性疾病的诊断灵敏度为46.8%,特异度为82.6%,阳性预测值59.5%,阴性预测值74.0%。结论血清HE4水平除了可以作为卵巢癌与部份子宫恶性肿瘤的辅助诊断标志物外,还应注意部份子宫腺肌病等妇女盆腔良性疾病患者血清HE4水平也可增高。

Objective To investigate the value of human epididymis secretory protein 4（HE4） diagnosis of patients with Gynecological Pelvic Lesions.Methods An Enzyme-linked immunosorbent assay（ELISA） Was used to detect the level of serum HE4.patients were divided into the following foure groups and evaluate the sensitivity,specificity and other diagnostic indicators according to their postoperative pathology results.Results The average value of serum HE4 in the healthy control group was 32.52±11.67 pmol/L,and in ovarian cancer group was 463.05±365.81 pmoL/L（100%）,in benign ovarian disease group was 40.55±18.88 pmoL/L（17.65%）,in uterus malignant tumor group was 59.47±40.78 pmoL/L（37.5%）,in benign uterus disease group was 42.74±18.33 pmoL/L（19.23%）.The sensitivity and the specificity and the positive predictive value and the negative predictive value of HE4 to detection gynecological pelvic neoplasms were 46.8%and 82.6% and 59.5% and 74.0% respectively.Conclusion Human Serum level of HE4 can is helpful in the diagnosis of ovarian cancer and uterus malignant tumor,but Serum level of HE4 can were higher than that healthy Reference values with a part of benign gynecological pelvic disease.