母体抗体效价检测在新生儿溶血病诊断中的应用

Relationship between maternal IgG antibody and hemolytic disease of newborn

目的探讨O型血孕妇产前IgG抗(A)B抗体效价与新生儿ABO溶血病的关系。方法采用微柱凝胶法动态监测745例O型血孕妇血清IgG抗(A)B抗体,并对高风险新生儿做溶血病血清学检测。结果孕妇血清抗体效价为1∶64、1∶128和≥1∶256时,新生儿ABO溶血病的发病率分别为10.32%、50.94%和85.71%,不同抗体效价组别间差异有统计意义(P<0.01)。结论 ABO溶血病的发病率随着孕妇血清抗体效价升高而升高,产前IgG抗体效价的动态监测对预防新生儿溶血病有重要意义。

Objective To study the relationship between the IgG antibody titer of pregnant women with blood type O and ABO hemolytic disease of newborn（ABO-HDN）.Methods To monitor sera IgG anti-（A） B antibody 745 cases of pregnant women with blood type O using micro-column gel dynamic and serological detection of hemolytic disease on high-risk newborns.Results When the valence of antibody was 1∶64,1∶128,1∶256 and more,the ABO-HDN incidence rates were 10.32%、50.94%、85.71% respectively.Statistically significants were detected between different antibody titers groups.Conclusion The more the titers of IgG antibody in the sera withpregnant women,the higher the incidence of ABO-HDN.So the IgG antibody titers monitoring of pregnant women were very important to the prevention of ABO-HDN.