中药对下肢深静脉血栓形成伴高凝状态的影响

The impact of TCM for lower extremity deep venous thrombosis associated with hypercoagulable state

目的:探讨活血化瘀中药对下肢深静脉血栓形成高凝状态的影响。方法:80例下肢深静脉血栓形成高凝状态的患者随机分为两组,治疗组40例用活血化瘀中药,同时给予西药常规治疗,对照组40例单纯用西药治疗,两组均治疗4周观察临床疗效及凝血指标的变化。结果:治疗组总有效率92.50%,对照组为80.00%,两组比较有显著性差异(P<0.05);治疗组血小板(PLT)、纤维蛋白原(FiB)、D-二聚体(D-dimer)治疗后明显低于治疗前(P<0.01),并且也明显低于对照组治疗后(P<0.01);凝血酶原时间(PT)、部分凝血活酶时间(APTT)治疗组治疗后比治疗前明显延长(P<0.05或P<0.01),并且明显优于对照组治疗后(P<0.05或P<0.01)。结论:加用活血化瘀中药能够很好地改善患者的高凝倾向,显示出中药疗效的确切性。

Objective： To investigate the impact of TCM for lower extremity deep venous thrombosis associated with hypercoagulable state. Methods： 80 patients were randomly divided into two groups, the treated group was treated in TCM, while given the conventional western medicine treatment, the control group was given the western medicine treatment, After 4 weeks of treatment, changes of the coagulation indicators and clinical efficacy in the two groups were observed. Results： The total effective rate of the treated group was 92.50%, and was 80.00% of the control group; PLT, FiB, the D-dimer in the treated group were significantly lower than before treatment （P0.01）, and were lower than that of the control group after treatment （P0.01）; PT, APTT in the treated group were significantly longer than before treatment （P0.05 or P0.01）, and significantly better than that of the control group after treatment （P0.05 or P0.01）. Conclusion： Accession of TCM could improve the patient＇s hypercoagulable tendency, showing the exact nature of the TCM.