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肿瘤坏死因子-α及转化生长因子-β1在肺纤维化形成中的作用研究进展 被引量：34

TNF alpha and TGF-β1 and the research progress of pulmonary fibrosis
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摘要 肺纤维化(pulmonary fibrosis,PF)是以慢性进行性弥漫性肺间质纤维化和限制性通气功能障碍为特点的肺间质性疾病。在早期表现为肺泡炎,最终导致不可逆性肺纤维化。本文就细胞因子(肿瘤坏死因子-α、转化生长因子-β1)在PF形成中的作用进行综述。
作者 于露 刘跃建
机构地区 泸州医学院 四川省医学科学院.四川省人民医院呼吸内科
出处 《实用医院临床杂志》 2012年第3期163-165,共3页 Practical Journal of Clinical Medicine
关键词 肺纤维化 间质性肺疾病 肿瘤坏死因子-Α 转化生长因子-Β1
分类号 R563.9 [医药卫生—呼吸系统] R392.114 [医药卫生—免疫学]
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参考文献21

  • 1N ieholson AG, Fulford LG, Golby TV, et al. The relationship between individual histologic fe-atures and disease progression inidiopathic pulmonary fibrosis [ J ]. Am JR espir CritMed, 2002, 166 (2) :173-177.
  • 2陈小兵,李为民,陈文彬.特发性肺纤维化药物治疗进展[J].实用医院临床杂志,2007,4(1):82-83. 被引量：4
  • 3Zhu Z, Zheng T, Homer RJ, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation [ J ]. Science ,2004,304 : 1678-1682.
  • 4Fujita M, Shanon JM, Morikawao K, et al. Overexpression of tumor necrosis factor-α diminishes pulmonary fi- brosis induced by bleomycin or transforming growth factor-β [ J ]. Am J ResPir Cell Mol Biol, 2003.29:669 -676.
  • 5Lugli SM, Feng N, Heim MH, et al. Tumor necrosis factor α enhances the expression of the interleukin ( IL ) 4 receptor a-chain on endothelia ceils increasing IL4 or IL-13- induced star6 activation [ J ]. J Biol Chem,1997,272(9) :5487-9544.
  • 6Driscoll KE, Maurer JK. Cytokine and growth factor release by alveolar maerophages : potential biomarkers of pulmonary toxicity [ J ]. Toxicol Pathology, 1991,19 : 398 -405.
  • 7Savici D, He B, Geist LJ, et al. Silica increases tumor necrosis factor (TNF) production, in part, by upregulating the TNF promoter [ J ]. Exp Lung Res, 1994,20:613- 625.
  • 8Lou J, Donati YR, Juillard P, et al. Platelets play an important role in TNF-induced micro vascular endothelial cell pathology [ J ]. Am J Pathol,2001,151 ( 5 ) : 1397-1405.
  • 9Elias JA, Freundlich B, Adams S. Regulation of human lung fibroblast collagen production by recombinant interleukin-1, tumor necrosis factor and interferon gamma[ J]. Ann NY Acad Sci, 1990,580: 233-344.
  • 10Sime PJ,Marr RA,Gauldie D,et al. Transfer of tumor necrosis factor-alpha to rat hmg induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta 1 and myofibroblasts[ J]. Am J Patho1,1998 ,153 :825-832.

二级参考文献34

  • 1胡永斌,初令,李翔,王金胜,沈明,曾庆富.转化生长因子β_1对人胚肺成纤维细胞平滑肌肌动蛋白α表达的影响[J].中华结核和呼吸杂志,2004,27(7):488-490. 被引量：9
  • 2特发性肺纤维化诊断及治疗（试行方案）[J].中华结核和呼吸杂志,1994,17(1):8-8. 被引量：103
  • 3支气管肺泡灌洗及灌洗液的细胞计数分类技术规范[J].中华结核和呼吸杂志,1994,17(1):10-10. 被引量：38
  • 4[1]American Thoracic Society.Idiopathic fibrosis:diagnosis an treatment.International Consensus Statement.American Thoracic Society and the European Respiratory Society[J].Am J Respir Crit Care Med,2000,161:646-664.
  • 5[2]Raghu G,Depaso WJ,Cain K,et al.Azathioprine combined with prednisone in the treatment of idiopathic pulmonary fibrosis:a prospective,double-blind randomized,placebo-controlled clinical trial[J].Am Rev Respir Dis,1991,144(2):291-296.
  • 6[3]Harold R,Jay H,William W,et al.Combined Corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis[J].Chest,2004,125:2169-2173.
  • 7[4]Lynch J,White E,Flaherty K.Corticosteroids in idiopathic pulmonary fibrosis[J].Curr Opin Pulm Med,2001,7(5):298-308.
  • 8[5]Shah NR,Noble PW,Jackson RE,et al.A critical assessment of treatment options for idiopathic pulmonary fibrosis[J].Sarcoidosis Vasc Diffuse Lung Dis,2005,22:167-174.
  • 9[6]Nicholson AG,Fulford LG,Golby TV,et al.The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis[J].Am J Respir Crit Med,2002,166(2):173-177.
  • 10[7]Nakazato H,Oku H,Yamane S,et al.A novel antifibrotic agent pirfenidone suppresses tumor necrois factor-αat the translational level[J].Eur J Pharmacol,2002,446(1-3):177-185.

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实用医院临床杂志
2012年 第3期

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