172例慢性乙肝患者血清乙肝病毒外膜大蛋白检测结果分析

目的:探讨乙肝患者血清中乙型肝炎病毒大蛋白(LHBs)检测的意义。方法:收集172例患者HBsAg阳性血清,应用ELISA方法检测LHBs、实时荧光法检测乙型肝炎病毒DNA,对相同乙型肝炎标志物模式血清LHBs阳性率与乙型肝炎病毒DNA阳性率结果进行分析。结果:相同乙型肝炎标志物模式血清LHBs阳性率与乙型肝炎病毒DNA阳性率差异无显著性(均P>0.05)。结论:LHBs和乙型肝炎病毒DNA的检出具有一致性,能够反映患者体内病毒复制情况,对诊断有较好的应用价值。

Objective： To investigate the hepatitis B virus large surface protein in the serum of patients with hepatitis B（Hepatitis B Virus is the Large the Surface the Protein,the LHBs） detection of clinical significance.Methods： 172 patients were HBsAg positive serum by ELISA the LHBs,real-time fluorescence detection of hepatitis B virus DNA,the positive rate of hepatitis B virus DNA positive rate in the same hepatitis B markers mode serum LHBs results were statistically analysis.Results： no significant differences in marker mode of the same hepatitis B serum the LHBs positive rate of hepatitis B virus DNA positive rate（all P 0.05）.Conclusion LHBs and hepatitis B virus DNA detection has a better consistency,to reflect the in vivo virus replication of the hepatitis B patients,the diagnosis of chronic hepatitis B patients have better value.