乙肝病毒X蛋白结合蛋白最新研究进展

Latest Research Progress on the Hepatitis B X-interacting Protein(HBXIP)

乙肝病毒X蛋白结合蛋白(HBXIP)是肝细胞癌变过程的一个关键因素,它能在动物肌肉组织和恶性肿瘤组织中过表达。近年来研究显示:HBXIP能与人体内多种蛋白结合。本文综述了HBXIP蛋白参与细胞凋亡与增殖、细胞周期进程、中心体复制、肿瘤细胞迁移等过程,以期为以HBXIP蛋白为靶标的新的抗乙肝病毒等药物设计提供基础。

The hepatitis B X-interacting protein（HBXIP） is a key factor in the process of canceration of liver cells,which can overexpress in animal muscle tissue and malignant tumors tissue.In recent years,studies have shown that HBXIP can bind a variety of proteins of the human body.In this review,we summarized the latest advances on the studies about how HBXIP is involved in cell apoptosis and proliferation,cell cycle progression,centrosome replication,and tumor cell migration through interaction with other proteins,in order to rationally design new anti-hepatitis B virus drug using HBXIP as a target in the future.