摘要
目的探讨甘草酸二铵辅助治疗重症急性胰腺炎(SAP)前后血浆Ghrelin,CRP,IL-8和TNF-α浓度的变化。方法 100例急性坏死性胰腺炎患者随机分为两组:甘草酸二铵辅助治疗组和一般治疗组。入院时(0 d)和治疗3 d后进行APACHE-Ⅱ评分;入院时(0 d)、治疗1 d和3 d后,观察血淀粉酶、血脂肪酶、血浆Ghrelin、CRP、IL-8和TNF-α浓度的变化。50例门诊体检健康成年人为对照组。结果甘草酸二铵辅助治疗组和一般治疗组患者APACHE-Ⅱ评分在治疗3 d后均明显下降,甘草酸二铵辅助治疗组下降更明显(P<0.05)。甘草酸二铵辅助治疗组和一般治疗组患者血淀粉酶、血脂肪酶、血浆Ghrelin、CRP、IL-8和TNF-α浓度均进行性下降,且甘草酸二铵辅助治疗组下降更明显(P<0.05)。结论甘草酸二铵对SAP有明显辅助治疗作用。血浆Ghrelin、CRP、IL-8和TNF-α浓度与SAP病情严重程度相关。
Objective To discuss the changes of plasma Ghrelin,CRP,IL-8 and TNF-α before and after the adjunctive therapy with diammonium glycyrrhizinate（DG）in patients with severe acute pancreatitis（SAP）.Methods 100 patients with SAP were randomly divided into two groups：DG adjunctive treatment group and normal treatment group.APACHE-Ⅱ scoring was made at the time of administration（0 d）and 3 d after the treatment.The changes of hemodiastase,lipase,plasma Ghrelin,CRP,IL-8 and TNF-α were observed at the time of administration,1 and 3 d after the treatment.Other 50 health adults were chosen as the control group.Results The APACHE-Ⅱ scores of DG adjunctive treatment group and normal treatment group all decreased significantly 3 d after the treatment,and the score of the former group decreased more obviously（P0.05）.The contents of hemodiastase,lipase,plasma Ghrelin,CRP,IL-8 and TNF-α in the two groups all decreased progressively,and those of DG adjunctive treatment group decreased more obviously（P0.05）.Conclusion DG has adjunctive therapeutic effects on SAP.The contents of plasma Ghrelin,CRP,IL-8 and TNF-α level has correlation with the severity of SAP.
出处
《西南国防医药》
CAS
2012年第5期500-502,共3页
Medical Journal of National Defending Forces in Southwest China
