血管紧张素Ⅱ受体拮抗剂治疗高血压的研究进展
被引量:1
摘要
血管紧张素(AT)受体拮抗剂能够作用于肾素—血管紧张素—醛固酮系统(RAAS),在对于高血压的治疗上有着重要的作用。它通过调整血管平滑肌细胞、心肌细胞来增加血管阻力和引起左心室肥厚等,现就AT受体拮抗剂与高血压之间的关系进行分析。
出处
《临床合理用药杂志》
2012年第14期168-169,共2页
Chinese Journal of Clinical Rational Drug Use
参考文献8
-
1Nickenig G,Baumer AT,Grohe C,et al.Estrogen modulates AT1 receptor gene expression in vitro and in vivo.Circulation,1998,97(22):2197-2201.
-
2Gohlke P,Pees C,Unger T.AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism.Hypertension,1998,3(Pt2)1:349-355.
-
3Carey RM,Wang ZQ,Siragy HM.Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function.Hypertension,2000,35(1Pt2):155-163.
-
4Fang TC,Huang WC.Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats.Hypertension,1998,32(2):235-242.
-
5Deb DK,Chen YZ,Zhang ZY,et al.1,25-D ihydroxyvitam in D3 sup-presses high glucose-induced angiotensinogen expression in kidney cells byblocking the NF-B pathway[J].Am J Physiol RenalPhysiol,2009,296(5):F1212-1218.
-
6Zeeuw D.,Agarwal R,Amdahl M,et al.Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes(VITAL study):a randomised controlled trial[J].Lancet,2010,376 (9752):1543-1551.
-
7王鲁雁,孙宁玲.血管紧张素Ⅱ受体拮抗剂(ARB)氯沙坦在高血压治疗中的作用及地位[J].中华高血压杂志,2007,15(z1):11-13. 被引量:8
-
8刘立新,周书明,姚依群.血管紧张素Ⅱ受体拮抗剂临床研究进展[J].实用医学杂志,2008,24(20):3457-3458. 被引量:8
二级参考文献17
-
1Dahlt~f B, Devereux R B, Kjeldsen S E, et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE) :a randomised trial against atenolol [J]. Lancet ,2002,359(9311 ) :995-1003.
-
2Lithell H, Hansson L, Skoog I, et al. The Study on Cognition and Prognosis in the Elderly (SCOPE) : principal results of a randomized double-blind intervention trial [ J ]. J Hypertens, 2003,21 (5) : 875- 886.
-
3Julius S, Kjeldsen S E, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial [J]. Lancet, 2004,363 ( 9426 ) : 2022-2031.
-
4Verma S , Strauss M. Angiotensin receptor blockers and myocardial infarction [J]. BMJ, 2004,329(7477) : 1248-1249.
-
5Dickstein K, Kjekshus J. OPTIMAAL Steering Committee of the OPTIMAAL Study Group. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction:the OPTIMAAL randomised trial. Optimal trial in myocardial infarction with angiotensin Ⅱ antagonist losartan [J].Lancet, 2002,360(9335):752-760.
-
6Pfeffer M A, McMurray J J, Velazquez E J, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both [J]. N Engl J Med, 2003,349 (20): 1893-1906.
-
7Verdecchia P, Angeli F, Gattobigio R, et al. Do angiotensin Ⅱ receptor blockers increase the risk of myocardial infarction [J]? Eur Heart J, 2005, 26(22) :2381-2386.
-
8McDonald M A, Simpson S H, Ezekowitz J A, et al. Angiotensin receptor blockers and risk of myocardial infarction : systematic review [J ]. BMJ, 2005,331 (7521) : 873.
-
9Lee V C, Rhew D C, Dylan M, et al. Meta-analysis: angiotensinreceptor blockers in chronic heart failure and high-risk acute myocardial infarction[J]. Ann Intern Med, 2004, 141 (9):693- 704.
-
10Pitt B, Segal R, Martinez F A, et al. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE) [J]. Lancet,1997,349 (9054) : 747-752.
共引文献14
-
1谭落娇,郑全慧,蒋文忠.老年高血压药物的合理应用[J].中国医药导刊,2009,11(7):1209-1210.
-
2潘磊,韩永鹏.几种血管紧张素Ⅱ受体拮抗剂类药物的研究进展[J].医学临床研究,2010,27(9):1778-1780. 被引量:1
-
3潘磊,韩永鹏.4种ARB类药物研究进展[J].中国老年保健医学,2010,8(5):63-64. 被引量:7
-
4李杰.沙坦类药物临床研究进展[J].淮海医药,2011,29(1):89-91. 被引量:8
-
5于玲,李寒.氯沙坦钾在维持性血液透析患者中的应用[J].中国血液净化,2011,10(7):382-384. 被引量:2
-
6舒永华,肖文星.高血压药物治疗的新进展[J].实用心脑肺血管病杂志,2012,20(3):385-386. 被引量:17
-
7王琳,董胜英,杨琳,乔成栋,刘永铭,杨京港,王金羊,刘艳英,陈敏娟,王岩.老年男性高血压并2型糖尿病患者服用安搏诺的临床观察[J].卫生职业教育,2012,30(10):142-143.
-
8李芳,王峥,成静,夏俊芝,谭含璇.高龄高血压患者血压昼夜节律与肾素-血管紧张素-醛固酮系统的关系[J].中华老年心脑血管病杂志,2012,14(8):874-875. 被引量:2
-
9李芳,王峥,成静,夏俊芝,谭含璇,王晶.高龄非杓型高血压患者睡前缬沙坦治疗的疗效观察[J].中华老年心脑血管病杂志,2012,14(12):1260-1262. 被引量:9
-
10向萍.氯沙坦与依那普利治疗轻中度原发性高血压的临床疗效对比[J].实用心脑肺血管病杂志,2013,21(2):69-70. 被引量:4
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-
1DAVIS B N, HILYARD A C, NGUYEN P H, et al. Induction of microRNA- 221 by platelet - derived growth factor signaling is critical formodulation of vascular smooth muscle phenotype[J]. J Biol Chem, 2009, 284(6): 3728-3738.
-
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-
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-
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-
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-
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-
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-
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