检测降钙素原及超敏C-反应蛋白在新生儿感染的临床意义

Clinical significance of procalcitonin and high-sensitivity C-reactive protein in neonatal infections

目的检测降钙素原和超敏C-反应蛋白,在新生儿感染中的临床意义。方法 2009年5月-2011年8月收治医院新生儿科和温州市儿童医院新生儿科,出生<1周的新生儿386例,其中159例为轻度感染,51例为重度感染,176例健康新生儿;比较治疗前3组新生儿降钙素原和超敏C-反应蛋白水平。结果检测健康新生儿组与重度感染组降钙素原分别为(0.61±0.32)、(5.27±2.64)g/L;超敏C-反应蛋白分别为(0.84±0.16)、(13.98±5.64)mg/L;外周血白细胞计数分别为(10.1±1.8)、(17.9±5.4)×109/L;中性粒细胞分别为(0.4±0.1)、(0.8±0.2)%,差异均有统计学意义(P<0.05),健康新生儿组与轻度感染组的降钙素原分别为(0.61±0.32)、(1.67±1.01)g/L,差异有统计学意义(P<0.05)。结论测定降钙素原能够更早期、更准确、更灵敏地诊断新生儿早期感染性疾病。

OBJECTIVE To detect the clinical significance of procalcitonin and high-sensitivity C-reactive protein in neonatal infections.METHODS From May 2009 to Aug 2011,totally 386 cases of infants born within 1 week in the department of neonatology in our hospital and Wenzhou Children′s Hospital were observed,among which 159 cases were with mild infections,51 cases were with severe infections,and 176 cases were healthy newborns;the levels of procalcitonin and C-reactive protein of the 3 groups were compared before treatment.RESULTS The levels of procalcitonin of healthy newborns group and the severe infections group were（0.61±0.32） g/L and（5.27±2.64） g/L;the levels of high-sensitivity C-reactive protein were（0.84±0.16） mg/L and（13.98±5.64） mg/L;WBC counts were（10.1 ±1.8）×109/L and（17.9±5.4）×109/L,neutrophils were（0.4%±0.1）% and（0.8±0.2）%,the differences were statistically significant（P〈0.05）;the levels of procalcitonin in healthy newborns and mild infections groups were（0.61±0.32） g/L and（1.67±1.01） g/L,the difference was statistically significant（P〈0.05）.CONCLUSION The determination of procalcitonin can help to diagnose the early infectious diseases in an a earlier,more accurate and susceptible manner.