横断面调查分析抗菌药物应用的综合管理成效

Cross-sectional survey of effect of integrated management of antimicrobial agents

目的通过横断面调查抗菌药物使用状况,分析医院实施综合干预前、后抗菌药物应用的管理成效,进一步促进临床合理用药。方法对医院综合干预前(2008年)和干预后(2010年)住院患者抗菌药物使用率横断面调查情况进行统计、对比与分析。结果抗菌药物使用率由2008年的55.7%下降至2010年的49.5%,差异有统计学意义(P<0.01);治疗性用药率由2008年的43.8%上升至2010年的54.8%,预防性用药率由2008年的38.2%下降至2010年的33.4%,差异有统计学意义(P<0.01),采取干预后,治疗性抗菌药物使用率、单一用药率及病原学送检率明显提高,抗菌药物使用率、无指征用药率明显下降。结论通过综合临床干预,可以达到逐步规范临床抗菌药物合理使用的目的。

OBJECTIVE To analyze the effect of management of antibiotics before and after integrated interventions through cross-sectional survey of current status of the use of antibiotics,so as to further promote the reasonable use of antibiotics.METHODS Cross-sectional survey of the use rates of antibiotics before（2008） and after（2010） the integrated intervention was conducted for statistics,comparison,and analysis.RESULTS The use rate of antimicrobial drugs decreased from 55.7% in 2008 to 49.5% in 2010,the difference was statistically significant（P〈0.01）;the therapeutic use rate rose from 43.8% in 2008 to 54.8% in 2010,and the prophylactic use rate dropped from 38.2% in 2008 to 33.4% in 2010,the difference was statistically significant（P〈0.01）,the therapeutic use rate,single-drug use rate,and the submission rate of etiology were significantly improved after the interventions,the use rate of antibiotics and the use rate without indications were remarkably decreased.CONCLUSION The integrated clinical intervention can help to achieve the purpose of standardized use of antibiotics step by step.