铜绿假单胞菌感染的分布及耐药性分析

Distribution of Pseudomonas aeruginosa infections and analysis of drug resistance

目的了解铜绿假单胞菌(PAE)感染的临床分布及其对常用抗菌药物的耐药性,为临床抗感染治疗提供依据。方法回顾2008年1月-2010年12月从临床标本中分离的PAE,分析其药敏结果。结果从各类标本中共分离出PAE 286株,标本来源以痰、创口分泌物为主,分别占67.8%、19.6%;感染分布以ICU、呼吸内科为主,分别占32.2%、23.4%;PAE敏感率较高的药物有阿米卡星、妥布霉素、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、亚胺培南,耐药率均<30.0%;耐药率较高的药物有头孢噻肟、磺胺甲噁唑/甲氧苄啶、庆大霉素和氨曲南,耐药率均>50.0%。结论临床应合理应用抗菌药物,减少耐药性的产生。

OBJECTIVE To investigate the clinical distribution and the drug resistance of Pseudomonas aeruginosa infection in order to provide basis for clinical anti-infections treatment.METHODS The specimens were collected from clinical patients with infections from Jan 2008 to Dec 2010,P.aeruginosa were isolated and the drug susceptibility was tested.RESULTS A total of 286 strains P.aeruginosa isolates were isolated from various specimens.Most of P.aeruginosa were cultured from sputum（67.8%） and wound secretion（19.6%）;the infections most frequently occurred in ICU（32.2%） and department of respiratory medicine（23.4%）;the result of drug susceptibility testing showed that the drug susceptibility rates of PAE to amikacin,tobramycin,cefoperazone/sulbactam,piperacillin/tazobactam,and imipenem were relatively high with the drug resistance rates less than 30.0%;the resistance rates to cefotaxime,sulfamethoxazole/trimethoprim,gentamicin,and aztreonam were higher than 50.0%.CONCLUSION Rational use of antibiotics is important for the reduction of bacterial resistance.