慢性肝病与肠道菌群的研究进展

The progress of researches on chronic liver disease and intestinal flora

肝脏与肠道微生态可谓息息相关,互为影响。慢性肝病患者均存在不同程度的菌群失调,而菌群失调与血内毒素水平升高相关,且可诱发肝性脑病、二重感染的发生。肠道菌群失调促进了慢性肝病并发症的发生、发展,增加了患者的死亡率,且菌群失调与肝功能损害程度成正比。微生态制剂可通过恢复肠道菌群平衡,维持肠道屏障的完整性,抑制产生内毒素的G-数量,减少肠氨的产生,辅助治疗慢性肝病。

The liver was closely related to gut microflora. Chronic liver disease patients had alteration of intestinal flora, which was associated with increasing endotoxin blood, hepatic encephalopathy, and the occurrence of superinfection. Imbalanced intestinal flora promoted the occurrence and progression of complications of chronic liver disease, increased mortality, and was proportional to the degree of liver dysfunction. Probiotics could restore intestinal flora balance, maintain the integrity of the intestinal barrier, inhibit the amount of G-, reduce the production of intestinal ammonia, and aid in the treatment of chronic liver disease.