不同频次甲硫咪唑治疗Graves病的疗效比较

Comparision on the effection of Graves' disease treated with different frequency methimazole

目的通过观察63例Graves病患者,比较甲硫咪唑每日单次30 mg与每次10 mg,每日三次治疗的疗效。方法将门诊确诊的初发的63例(女性45例,男性18例)Graves病患者,随机分为单次组和多次组两组,采用组间t检验及卡方(χ2)检验比较两组治疗期间缓解率、药物副作用发生率及停药后复发率。结果两组的缓解率有显著性差异(P<0.05);药物副作用发生率两组间无明显差异;治疗满2年后,停药6月时观察两组的复发率有显著性差异(P<0.05)。结论相较于传统的给药方式,甲硫咪唑每日一次30 mg不会明显增加药物副作用,有利于提升患者的依从性从而提高甲亢缓解率、降低复发率。

【Objective】Through the observation of 63 cases of patients with Graves disease,to compare Tapazole single daily 30 mg and each 10 mg three times daily treatment efficacy.【Methods】The outpatient diagnosis of the initial issuance of the 63 cases（45 cases of female,male 18 cases） in patients with Graves＇ disease,were randomly divided into a single group and multiple group two groups,using group t-test and chi-square（χ2） test was used to compare two groups during the treatment response rate,the drug incidence of side effects and relapse rate after discontinuation.【Results】The remission rates in both groups have significant difference（P0.05）;no significant difference in the incidence of adverse drug reactions between the two groups;treatments at least 2 years after the recurrence rate of withdrawal in two groups were observed in June were significantly different（P0.05）.【Conclusion】Compared to the traditional delivery method,Tapazole once a day 30 mg does not significantly increase the drug side effects,but can enhance patients adherence to higher hyperthyroidism remission rate with lower relapse rate.