不同剂量盐酸坦洛新缓释片治疗早泄的临床疗效

Clinical efficacy of tamsulosin hydrochloride sustained release tablets in treatment of premature ejaculation

目的探讨不同剂量盐酸坦洛新缓释片治疗早泄的临床疗效。方法2010年9月至2011年1月收治的早泄患者80例，随机数字表法均分为0．2和0．4mg盐酸坦洛新缓释片组，观察临床疗效和治疗前后患者CIPE-5评分的变化，并进行组内和组间比较。结果两组各脱落2例，原因均为服药后出现头晕、眩晕、体位性低血压。0．2和0．4mg组患者治疗前阴道内射精潜伏期分别为（0．98±0．47）、（0．89±0．47）min，治疗后分别为（4．40±1．86）、（6．40±5．10）min，差异有统计学意义（P〈0．01）。在夫妻性生活满意度、性生活焦虑减轻程度及延迟射精困难减轻程度方面，0．4mg组均优于0．2mg组。结论大剂量、长周期盐酸坦洛新缓释片治疗早泄可延长射精潜伏期，提高夫妻性生活满意度。

Objective To study the efficacy of different doses of tamsulosin hydrochloride sustained release tablets for treatment of premature ejaculation （PE）. Methods Eighty PE patients from September 2010 to January 2011 were divided into two groups randomly, the 0.2 mg dose group and the 0.4 mg dose group. The therapeutic effect was assessed by the changes of the patients＇ CIPE-5 scores. Results The intra-vaginal ejaculation latency time （IELT） of the two groups were （0.98 ± 0. 47 ） and （0.89 ± 0.47 ） min respectively before treatment, and （4.40 ± 1.86） and （6.40± 5.10） min respectively after treatment. There were significant differences （ P 〈 0.01 ）. As for satisfaction degree of sexual life, lessening the patients＇ sexual anxiety and nervousness, and decreasing the difficulty in retarding ejaculation, the group of 0.4 mg had better effeet than the other group. Conclusion Large dose of tamsulosin hydrochloride sustained release tablets could prolong IELT and increase the sexual satisfaction.